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《Journal of Guangzhou University of Traditional Chinese Medicine》 2008-01
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Experimental Study of Shengjiang Powder on Treating Acute Lung Injury

CHANG Jiasong,WEI Kaifeng,PAN Yun(Basic Medicine College,Nanjing University of Chinese Medicine,Nanjing 210029 Jiangsu,China)  
Objective To investigate the therapeutic mechanism of Shengjiang Powder(SP)on acute lung injury.Methods Forty healthy SD male rats were divided into 3 groups randomly: normal group,model group,and SP group.After administration for 6 days,acute lung injury rat models were established by injecting lipopolysaccharide(LPS)into sublingual vein.Lung histological sections were prepared for the detection of NF-κB expression by immmunohistochemistry.The images of the lung histological sections were captured and the average gray values of nucleus of endothelial cells in lung micrangium were measured.Results Compared with the model group,SP could depress the expression of NF-κB in the nucleus of lung microvascular endothelial cells,and statistical difference existed between the two groups(P0.01).Conclusion SP has preventive and therapeutic effect on acute lung injury by inhibiting inflammatory damage on lung tissues through depressing the expression of NF-κB in the nucleus of endothelial cells in lung micrangium.
【Fund】: 南京中医药大学自然科学基金(编号:05XZR01)
【CateGory Index】: R285.5
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