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《Journal of Guangzhou University of Traditional Chinese Medicine》 2014-01
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Anti-influenza A Virus Effect of Yinqiao Chaigui Granula in Vivo

XU Xiuni;ZHAO Jing;DAI Wanjuan;SHAO Minming;JIANG Yi;XIE Wenfang;ZUO Junling;ZHANG Fengxue;Institute of Tropical Medicine, Guangzhou University of Chinese Medicine;The First Affiliated Hospital, Guangzhou University of Chinese Medicine;  
Objective To investigate the effect of Yinqiao Chaigui Granula on counteracting influenza A virus in vivo. Methods NIH mice were randomized into normal control group, model group, positive control group(treated with virazole 100 mg·kg-1·d-1), and high-, middle- and low-dose Yinqiao Chaigui Granula groups(at the dosage of 6, 3 and 1.5 g·kg-1·d-1, respectively). The NIH mouse model of viral pneumonia was established by infection with pulmonary adaptive influenza A virus strain FM1. Lung wet-to-dry weight ratio, death rate, and pathological changes of lung tissue were observed to investigate the effects of Yinqiao Chaigui Granula on preventing and treating the infected mice. Results Lung wet-to-dry weight ratio and death rate were significantly increased in model group(P 0.01 compared with those in the normal control group) and the inflammatory changes of lungs were shown obviously. Yinqiao Chaigui Granula had obvious effect on decreasing lung wet-to-dry weight ratio and death rate( P 0.05 or P 0.01 compared with the model group), and on relieving the lung inflammatory changes, the effects being similar to those of virazole group. Conclusion Yinqiao Chaigui Granula exerts certain anti-influenza A virus effect in vivo.
【Fund】: 国家科技重大专项课题(编号:2011ZX09102-009-06);; 广东省科技计划项目(编号:2010B031600269)
【CateGory Index】: R285.5
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