Genitality in SD Rats with Spleen Deficiency and Kidney Deficiency

Zhou Ying(advisors: Liang Guozhen Luo Songping) Seven-year-graduate Class, Grade 91, Guangzhou University of TCM, Guangzhou 510407  

Genitality in female SD rats with spleen deficiency and kidney deficiency was observed systematically. The spleen-deficiency rat(SDR) model was set up with injection of reserpine and kidney_deficiency rat (KDR) model by gastric infusion of hydroxycarbamide. Si Junzi Tang and Shenqi Tang were used to recover the SDR and KDR respectively. Rats were allocated to five groups: SDR group, Si Junzi Tang SDR group, KDR group,Shenqi Tang KDR group and normal control group. It was found that results in the rats with deficiency syndromes were similar to those in human being,for instance, sexual cycle became irregular or even disappeared; genital organs went atrophy; the level of serum FSH and estradiol decreased; the numbers of uterine glands, secondary follicle and mature follicle lowered and the genitality decreased. The above changes occurred in the KDR especially. Symptoms in the deficiency syndromes were improved by invigorating the spleen and tonifying the kidney. The genitality was obviously increased in Shenqi Tang KDR group. It is indicated that in SDR the digestive function is affected directly and the endocrine function indirectly (including hypothalamus_hypophysis_gonad axis,i.e.,HHG axis), while in KDR, HHG axis is affected directly. Both Si Junzi Tang and Shenqi Tang can regulate HHG axis. The theory of deficiency spleen involving the kidney and the kidney controlling the genitality in TCM was also discussed.

【Key Words】： FERTILITY/drug eff. KIDNEY DEFICIENCY SHENQI PILL SPLEEN DEFICIENCY SIJUNZI DECOCTION WOMEM(FEMALE) DISEASE MODEL ANIMAL RATS
【Fund】： 国家中医药管理局资助
【CateGory Index】： R271.140.5

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