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The gestational diabetes mellitus and insulin resistance

YI Hua-ni,LI Juan,BAI Jing,SUN Qian,PENG Ting(Jinan Municipal Materntal and Child Health Hospital,Shandong Jinan 250001,China)  
Insulin resistance(IR) in pregnancy is prone to induce gestational diabetes mellitus(GDM).Genetic factors,insulin signaling system,placental factors,glucose transport protein,PC-1,TNF-α and LEP all participate in IR mechanisms,and they are associated with development of GDM closely.Referring to the domestic and foreign literatures,in this article,we summarized roles of these factors participating in IR in mechanism of GDM.
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