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《Chinese Journal of Maternal and Child Health Research》 2006-06
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Review and evaluation of methodology of research on DNA methylation

GU Ting-ting~(1,2),ZHANG Zhong-ming~1,ZHENG Peng-sheng~(1,2)(1.Department of Gynecology and Obstetrics,The First Affiliated Hospital of Medical College,Xi'an Jiaotong University,Shaanxi Xi'an 710061,China;2.Key Laboratory of Environment and Genes Related to Diseases,Medical College,Xi'an Jiaotong University,Ministry of Education,Shaanxi Xi'an 710061,China)  
DNA methylation,a very important component in epigenetics,plays important roles in maintaining normal cellular functions,gene imprinting,embryonic development,and human tumorigenesis,and now it becomes one of the hot points of research.With progresses in study on methylation,sorts of detecting techniques of methylation have been developed to meet requirements of various researches.These research methods can be classified into three groups: genome-wide methylation analysis,gene-specific methylation analysis and newly methylated sites screening.In this article,we introduced existing DNA methlylation detecting techniques and summarized their own characteristics at the same time.
【CateGory Index】: R346
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