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《Sichuan Journal of Zoology》 2005-01
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Gene Expression and Its Control of Early Embryo in Mammals

WANG Zheng-chao, WANG Feng~*, ZHOU Dong-ren, PAN Xiao-yan (Center of Animal Embryo Engineering and Technology, Nanjing Agricultural University, Nanjing 210095)  
The early development of mammalian includes the formation of the zygote, the activation of the embryonic genome (EGA), and the beginning of cellular differentiation. During this period, histones replace protamines, the methylated haploid parental genomes undergo demethylation following formation of the diploid zygote, and maternal control of development is succeeded by zygotic control. Embryonic genome activation is just after the formation of a chromatin-mediated transcriptionally repress state, gene expresses efficiently requiring enhancer.The development of this transcriptionally repressive state more likely occurs at the level of chromation structure, because inducing histone hyperacetylation can relive the requirements for enhancers. Characterization of zygotic mRNA expression patterns during the early period and their relationship to successful development in vitro and in vivo will be essential for defining optimized culture conditions and nuclear transfer progress.
【Fund】: 江苏省自然科学基金 (BK2003075)
【CateGory Index】: Q953
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