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《Sichuan Journal of Zoology》 2009-03
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Morphological Observation and Study on the Development of the Heart in Mice

TANG Juan1,2,LIU Yan2,YANG Guang2,WANG Wen-dong3,YIN Hai-lin2*(1.College of Life Sciences,Sichuan University,Chengdu 610064,China;2.Laboratory Animal Center,Sichuan University;3.West China School of Public Health,Sichuan University)  
Objective To figure out a pattern of the morphologic characterization and the time-table on development of mice hearts.Methods The transverse and vertical sections of the developing heart at ED8.5,ED9.5,ED10.5,ED11.5,ED12.5,ED14.5,ED16.5,ED18.5,P1(postnatal day 1) were stained with hematoxylin and eosin(HE) and morphologic observation was performed by graphic analysis system of PETV.Results ⑴Spatiotemporal development pattern of the cell structure: ①The cardiogenic plate developed at ED8.5;The cardiac muscle cell at ED9.5 was irregularly spindly and the cell size was more variable with many cell nuclei smaller than the ones at ED11.5.At ED10.5 tiny blood vessels in the myocardium first appeared and the myofibril,which was weakly stained compared to the cardiac muscle cell,first appeared in the ventricle.At ED11.5,the cardiac muscle cells arranged regularly and formed a longitudinally and obliquely sectioned cardiac muscle fiber.At ED12.5 the cell nuclei were clear stained and cardiac muscle cell became progressively more regular and well connected to each other.The intercalated disk was also found in ventricle myocardium at the same time.② At ED12.5 the cardiac trabecular structures in ventricle were first observed,which were becoming thicker at ED14.5,whereas there were fewer in atrium during this period.⑵ The structural formation of the ventricle and maturation of the mouse heart: ① The myocardial matrix network was evident in ventricle at ED10.5,the endocardium of ventricle appeared and epicardium of ventricle became identifiable at ED11.5.②The atrioventricular septum formed completely at ED12.5.The endocardial cushion occurred at ED12.5 which grew rapidly as result of the interventricular spetum completed at ED14.5 ③At ED16.5,the pericardium was identifiable and the cavity of pericardium formed while the whole proximal outflow tract septum was mostly occupied by myocardium.Conclusion The simultaneous appearance of myofibril and myocardial matrix network suggests that myofibril contribute to the formation of cell structure and the myocardialization.The structural alteration of the cell and the process of maturation of myocardium revealed regional differences in various parts of the embryonic heart.The ventricle shows a relatively slower pace of maturation compared with atrium.
【CateGory Index】: Q954
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Chinese Journal Full-text Database 6 Hits
1 PI Hualiang1, ZHANG Duhua2, LI Yongqing1, ZHU Chuanbing1, YUAN Wuzhou1, WU Xiushan1(1.Department of Molecular Development Genetics, College of Life Science, Hunan Normal University, Changsha 410081, China)(2.Obstetrics Department, Hospital of Health Care of Hunan Women and Children, Changsha 410078, China);Embryology Observation on Drug Abortive Embryos at Early Stages[J];Journal of Natural Science of Hunan Normal University;2002-04
2 Zhao Genran;Ling Fengdong;Liu Quanlu Department of Antomy,Xi'an Medical University,Xi'an 710061;AN OBSERVATION OF THE SUPRAVENTRICULAR CREST IN HEARTS[J];Chinese Journal of Anatomy;1993-05
3 PI Hua liang, LI Yong qing, WU Xiu shan (College of Life Sciences, Hunan Normal University, Changsha 410081, Hunan, China);The Morphological Study on Development of Cardiovascular System in Human Embryos[J];Life Science Research;2001-S1
4 Tian Zhenjun 1,Yang Zhangmin 2 (1 Department of Physical Education;2 Experimental Center, Shaanxi Normal University, 710062 Xi′an, Shaanxi, PRC);Scanning electron microscopic observation of intermyocardial collagen network in rats[J];JOURNAL OF SHAANXI NORMAL UNIVERSITY(NATURAL SCIENCE EDITION);1999-02
5 Tang Cheng-chun, Huang Jun Tang Cheng-chun,Huang Jun,Department of Cardiology, First Affiliated Hospital,Nanjing Medical University, Nanjing 210029, Jiangsu Province, China;Feasibility of cardiac fibroblasts differentiated into myocardial cells in rats[J];Chinese Journal of Clinical Rehabilitation;2005-07
6 PENG Tao~1, HUANG Guo-ying~1, ZHAO Xiao-qing~1, XIE Li-jian~1, QI Chun-hua~1, ZHOU Guo-min~2(1. Pediatric Cardiovascular Center, Chidren's Hospital of Fudan University, Shanghai 200032, China; 2. Department of Anatomy, Histology and Embryology, Fudan University Shanghai Medical School, Shanghai 200032, China);In vitro Culture and Biological Properties of Cardiac Neural Crest Cells of Mouse Embryo[J];Acta Laboratorium Animalis Scientia Sinica;2006-02
Chinese Journal Full-text Database 10 Hits
1 XIE Yong-fang, SHU Kun-xian, LIANG Yi-long, et al(Biology College, Chongqing University ofPosts and Communications, Chongqing 400065, China);Cell Proliferation and Apoptosis in the Developing Intestine of Mouse[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-01
2 Lu Yaping\ \ Hua Tianmiao\ \ Chen Bihui (Department of Biology, Anhui Normal University ,241000, Wuhu, Anhui, PRC) Wang Renping (Alligator Research Center of Anhui Province, 242000,Xuanzhou, Anhui, PRC);HISTOGENESIS OF THE DUODENUM OF ALLIGATOR SINENSIS EMBRYOS[J];Journal of Anhui Normal University(Natural Science);1998-03
3 ZHU Dao-Yu (Department of Life Science of Heze University,Heze 274015,China);Morphological and Histological Observation on the Eye Development of Trionyx sinensis[J];Chinese Journal of Zoology;2008-04
5 FU Wen-dong, SUN Yu-cheng,SUO Lun ,GAO Jian-ming~*(Beijing Agricultural College, Beijing 102206);Observation of Estrous Cycle and Choice of Optimal Superovulation Time in Mice[J];Journal of Beijing Agricultural College;2005-02
6 XIE Yong fang, LIANG Yi long, WANG Guang li (College of Biology Information,CUPT,Chongqing 400065, P.R.China);Cell Proliferation Apoptosis and the Expression of Related Genes in the Developing Liver of Mouse[J];Journal of Chongqing University of Posts and Telecommunications;2003-01
7 CHAI yi College of Animal Science,Yangtze University,Jingzhou,Hubei 434025,China;Huazhong Agricultural University Fishery College,Wuhan,Hubei 430070,China;Key Laboratory of Freshwater Fish Germplasm Resources and Biotechnology,Ministry of Agriculture,Yangtze River Research Institute,Chinese Academy of Fishery Sciences,Jingzhou,Hubei 434000,China XIE Cong-xin(Huazhong Agricultural University Fishery College,Wuhan,Hubei 430070,China)WEI Qi-wei Key Laboratory of Freshwater Fish Germplasm Resources and Biotechnology,the Ministry of Agriculture of PRC,Yangtze River Research Institute,Chinese Academy of Fishery Sciences,Jingzhou,Hubei 434000,China;Development of Taste Bud in Barbell of Chinese Sturgeon[J];Journal of Yangtze University(Natural Science Edition)Agricultural Science Volume;2007-03
8 Zai Baoxiang Liu Wei Li Hua Liu Huanliang(De; artment of Aquaculture);The Histological Study on the Germination and Development of the Pharyngeal Tooth and Callous Pad of the Black Carp (Mylopharygodon Piceus)[J];Journal of Dalian Fisheries University;1988-01
9 Chen Yiyu (Biology Department of Nanjing University 210008) Zheng Yishou (Medical College of Nanjing University) Shi Weikang (Shanghai Institute of Cell Biology, Academic Sinica);IMMUNOFLUORESCENT LOCALIZATION OF EPIDERMALGROWTH FACTOR RECEPTOR DURINGDEVELOPMENT OF MOUSE FETUS[J];Zoological Research;1992-04
10 Chang Qing Rong Chengxing Zhng Shiming(Department of Histoldgy & Embryology, Medical College, JINAN University, Guangzhou, 510632) ( Department of Histology & Embryology, Medical College, Hubei Medical University, Wuhan, 430070 );EFFECTS OF FLUORIDE EXPOSURE OF FEMALE MICE ON THE THYROID'S MORPHOLOGY AND FUNCTION AS WELL AS ONTOGENY OF FETUSES AND NEOBORNS[J];;1997-02
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 Xiong Zhengying Physical Education Department,Shanxi Normal University,Xi'an,China 710062;Experimental Research on Changes in Myocardial Collagen Content and Diastolic Function of Rats left Cardiac Ventricle Under Exercise Overload and Pressure Overload[J];Sport Science;1996-06
2 HOU Ling ling,ZHANG Yong(College of Animal Science and Veterinary Medicine,Northwest Science and Technology University ofAgriculture and Forestry,Yangling,Shaanxi 712100,China);A morphological study of the genesis and development of goat embryo heart[J];The Journal of Northwest Agricultural University;2001-01
3 Lu Xinzheng,Huang Jun,Ma Genshan,Hou MaihuaLu Xinzheng, Huang Jun, Ma Genshan, Department of Cardiology,First Affiliated Hospital, Nanjing Medical University,Nanjing 210029,Jiangsu Province,ChinaHou Maihua,Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital,Nanjing University Medical School, Nanjing 210008,Jiangsu Province,China;Effects of 5-azacytidine on expression of β-myosin heavy chain in cultured rat bone marrow stromal cells[J];Modern Rehabilitation;2003-09
4 ZHAO Xiao qing 1, HUANG Guo ying 1, CHEN Ping 2, XIE Li jian 1, ZHOU Guo min 3( 1 Pediatric Heart Center, Children's Hospital of Fudan University, Shanghai 200032, China; 2 Obstetrics and Gynecology Hospital of Fudan University;3 Department of Anatomy, Histology and Embryology, Shanghai Medical School of Fudan University);Process and Mechanism of Fusion and Myocardialization of Cardiac Proximal Outflow Tract in Mouse Embryos[J];Acta Laboratorium Animalis Scientia Sinica;2005-02
5 Yang Shengjie;Observation of Supraventricular Crest and Its Clinical Significance[J];;1987-03
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