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《Sichuan Journal of Zoology》 2009-03
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Morphological Observation and Study on the Development of the Heart in Mice

TANG Juan1,2,LIU Yan2,YANG Guang2,WANG Wen-dong3,YIN Hai-lin2*(1.College of Life Sciences,Sichuan University,Chengdu 610064,China;2.Laboratory Animal Center,Sichuan University;3.West China School of Public Health,Sichuan University)  
Objective To figure out a pattern of the morphologic characterization and the time-table on development of mice hearts.Methods The transverse and vertical sections of the developing heart at ED8.5,ED9.5,ED10.5,ED11.5,ED12.5,ED14.5,ED16.5,ED18.5,P1(postnatal day 1) were stained with hematoxylin and eosin(HE) and morphologic observation was performed by graphic analysis system of PETV.Results ⑴Spatiotemporal development pattern of the cell structure: ①The cardiogenic plate developed at ED8.5;The cardiac muscle cell at ED9.5 was irregularly spindly and the cell size was more variable with many cell nuclei smaller than the ones at ED11.5.At ED10.5 tiny blood vessels in the myocardium first appeared and the myofibril,which was weakly stained compared to the cardiac muscle cell,first appeared in the ventricle.At ED11.5,the cardiac muscle cells arranged regularly and formed a longitudinally and obliquely sectioned cardiac muscle fiber.At ED12.5 the cell nuclei were clear stained and cardiac muscle cell became progressively more regular and well connected to each other.The intercalated disk was also found in ventricle myocardium at the same time.② At ED12.5 the cardiac trabecular structures in ventricle were first observed,which were becoming thicker at ED14.5,whereas there were fewer in atrium during this period.⑵ The structural formation of the ventricle and maturation of the mouse heart: ① The myocardial matrix network was evident in ventricle at ED10.5,the endocardium of ventricle appeared and epicardium of ventricle became identifiable at ED11.5.②The atrioventricular septum formed completely at ED12.5.The endocardial cushion occurred at ED12.5 which grew rapidly as result of the interventricular spetum completed at ED14.5 ③At ED16.5,the pericardium was identifiable and the cavity of pericardium formed while the whole proximal outflow tract septum was mostly occupied by myocardium.Conclusion The simultaneous appearance of myofibril and myocardial matrix network suggests that myofibril contribute to the formation of cell structure and the myocardialization.The structural alteration of the cell and the process of maturation of myocardium revealed regional differences in various parts of the embryonic heart.The ventricle shows a relatively slower pace of maturation compared with atrium.
【CateGory Index】: Q954
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