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《Sichuan Journal of Auatomy》 1998-04
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An Experimental Study on L-cell HRF Induced by TSPG

Huang Xiaogin Zhu BideDepartment of Anatomy, Sichuan Continuing EducationCollege of Medical Sciences, Chengdu 610041  
For exploration the effect of thc main component of Chinese mediclnc Panaxginseng-to-tal saponins of Panaxginseng (TSPG) on regulation of hematopoiesis, wc uscd L-cell condi-tioned mcdium (LcCM ) induced by TSPG (LcCM.TSPG) to replacc exogencous hcmatopoiesisgrowth factor (HGF) in vitro hematopoietic progenitor culture. The result showcd: Thecolony number of CFU-GM in LcCMTSPG group decreased as compared with LcCM group,but that of BFU-E and CFU-E increased. The colony number of CFU-GM and BFU-Ein LcCM+TSPG group incrcased, as compared with that of LcCM group, but that of CFU-E was no significant different. The result suggests that TSPG may induce L-cell to se-cretc sclectioely CFU-GM inbibitor and,BFU-E and CFU-E growth factor; TSPG maycooperate also with the growth factors in LcCM of CFU-GM and BFU-E. It means thatTSPG may induce L -cell to produce hematopoiesis regulatory factor (HRF) or cooperatewith LcCM HRF to regulate hematopoiesis.
【CateGory Index】: R331.2
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