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《Sichuan Journal of Anatomy》 2007-01
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The Expression of BDNF and TrkB in the Spinal Cord of Adult Rhesus Monkeys

Sun Ling1,Qi Jian-guo1*,Zhang Wei1,Wang Ting-hua2,Wang Fang1,Lu Yong-chao3,Wen shilei1(1.Department of Histology,Embryology and Neurobiology,West China Schoolof Preclinical and Forensic Medicine,Sichuan University,Chengdu 610041,China;2.Institute of Neuroscience,Kunming Medical College,Kunming 650031,China;3.Division ofReproduction and Stem cell,Henan Institute of Planned Parenthood Research,Zhengzhou 450002,China)  
Objective To observe the distribution of both BDNF and its receptor TrkB in the spinal cord of normal adult rhesus monkeys,and to give the morphological data for their functional study.Method Five healthy,adult and male rhesus monkeys of Yunnan,China,were used in the experiment.The animals were perfused with 4% paraformaldehyd solution through aorta.The T8 spinal cord was taken out and fixed further with the same fixative,and then was kept in 20% sucrose solution over night.The tissue blocks were cut into frozen sections with a cryostat.The immunohistochemistry SP method was performed on two sets of those sections by using specific BDNF and TrkB antibody respectively.The distribution of positive BDNF and TrkB immunoreactivities in the spinal cord of the adult rhesus monkey was observed.Results Both BDNF and TrkB positive immunoreactive neurons were found distributed in the ventral horn and lateral horn and the neighboring region of the central canal of the gray matter of the thoracic cord in the adult monkey.The positive immunoreactive products were mainly in the cytoplasm with a clear demarcation with its nucleus.The nuclei were not stained in the positive BDNF immunoreactive neurons,but a diverse staining was found in the different positive TrkB immunoreactive neurons.Conclusion Both BDNF and TrkB express in the spinal cord of the adult rhesus monkey.They may be involved in the physiological function and recovery process after injury of the spinal cord.
【CateGory Index】: R329
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