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The Experimental Study on L cell Regulate Hematopoiete Effected by IL 1

Huang Xiaoqin,Zhu Bide∥Sichuan Continuing Education College of Medical Science,Cheng du 610041  
Objective:To explore the relationship between IL 1 and L cell in hematopoiesis,provide experimental fact to theory of stramal cell regulate hematopoiete.Methods:Use L cell conditioned medium induced by different concentration IL 1(LcCM IL 1 )or not (LcCM) as well as LcCM and IL 1 (LcCM+IL 1) in stead of exogeneous hematopoitic growth facter in hemato poitic progenitor culture in vitro,then compare the progenitor colony numbers.Results:The numbers of progenitor colony in group of LcCM were:CFU GM:52±8.4,BFU E:34±6.6,CFU E:100±13,in the group of LcCM IL 1 were CFU GM:24±7.5,BFU E:32±6.3,CFU E:146±11.2,the P 0.05 in CFU GM and CFU E.In the group of LcCM+IL 1,the numbers were CFU GM:54±8.9,BFU E:31±5.9,CFU E:121±12.4,all the P 0.05 compared with the group of LcCM.Conclusion:IL 1 can induce L cell produce hematpoitic inhibit facter witch inhibit CFU GM only and hematopoitic growth facter which stimulate CFU E.There is no cooperation between IL 1 and the hematopoietic regulate facter which produce by L Cell,The effection of IL 1 on Fibroblast regulate hematopoiete was different as diffrent source of Fibrblast.
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