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《Sichuan Journal of Physiological Sciences》 2010-03
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Study on synthesis of oxiracetam

Lu Kai-xuan,Liao Quan,Ren Yong,Wan Shun(Hunan Jianlang Pharmaceutical Co.,LTD.,Hunan Yueyang 414000)  
Objective: To study the synthesis of oxiracetam.Method: Oxiracetam was synthesized by ethyl-4-chloro-3-hydroxybutyrate and Glycinamide hydrochloride.Molar ratio of raw materials,reaction time,reaction temperature and catalytic quantity were investigated.Results: Under the best conditions its yield was 48.9%.Conclusions: Better technique condition was acquired.
【CateGory Index】: TQ465
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 WANG Shu-zhen~(1*) CHI Zhao-fu~1 MA Lin~1 ZHANG Yong~2 DI Qing~3 HAN Zhao~4 YU Hao~5 HAN Ting~6 (1.Department of Neurology,Qilu Hospital of Shandong University,Ji-nan SHANDONG 250012,China:2.Department of Neurology,Shandong Provincial Hospital,Ji-nan SHANDONG 250021,China;3.Department of Brain Hospital of Nanjing Medical University,Nanjing JIANGSU 210029,China;4.The First Affiliated Hospital of Wenzhou Medical College,Wenzhou ZHEJIANG 325000,China;5.Department of Epidemiology and Biostatistics School of Public Health,Nanjing Medical University,Nanjing JIANGSU 210029,China;6.Shijiazhuang Pharmaceutical Group Ouyi Pharmaceutical Company,Shijiazhuang HEBEI 050051,China);A randomized double-blind controlled multicenter study with oxiracetam for injection in treatment of organic brain syndrome[J];Chinese Journal of New Drugs and Clinical Remedies;2007-04
2 WANG Shu-zhen1,CHI Zhao-fu1,GUO Hong-zhi1 ,ZHANG Yong2 ,LUO Ben-yan3,PEI Hai-tao4,XING Cheng-ming5 ,SUN Rui-ruan6(1.Department of Neurology,Qilu Hospital of Shan dong University,Jinan 250012,China;2.Department of Neurology,Shandong Province Hospital,Jinan 250021,China;3.First Affiliated Hospital of Zhejiang Medical University,Hangzhou 310003,China;4.Affiliated Hospital of Qingdao Medical College,Qingdao 266003 ,China;5.Qingdao Shili Hospital,Qingdao 266011,China;6.Drug Clinical Evaluate Center of Anhui Province,Wuhu 241001,China);A Randomized Double-Blind Controlled Multicenter Study with Oxiracetam in Treatment of Organic Brain Syndrome[J];Chinese Pharmaceutical Journal;2007-15
【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 SHU Kai, XI Gui-fa, NIU Hong-quan, DONG Zhen, YU Jia-sheng, LEI Ting, LI Ling. Department of Neurosurgery, Tongji Hospital, Tongji Medical College, H uazhong University of Science and Technology, Wuhan 430030, China;Clinical evaluation of Oxiracetam in the treatment of craniocerebral trauma[J];Chinese Journal of Neuromedicine;2005-05
2 FANG Bo,CAI Yun-hong,YUAN Peng,et al.(1.Department of Neurosurgery;2.Department of Neurology,Emergency Medical Center of Chongqing,Chongqing 400014,China);Clinical study of treating impediment of anamnesis and aptitude in the convalescent patients with severe head injury by oxiracetam[J];Chongqing Medical Journal;2005-11
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【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Hai li bi nu er, WANG Yin hua, ZHAO Fa guo (Department of Neurology, The First Hospital of Peking University, BEIJING 100034, China);Randomized double-blind controlled study of oxiracetam vs piracetam in treatment of vascular dementia[J];Chinese Journal of New Drugs and Clinical Remedies;2003-11
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