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《Sichuan Medical Journal》 2007-06
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Preliminary stuty on therapeutic effect of oxymatrine in treating patients with chronic hepatitis C

Yu Guiqin1,Zhou Xiaohui2,Shi Xiaohua1,et al.1.The Second Affiliated Hospital of Shantou University,Shantou,Guangdong 515065;2.The First Affiliated Hopsital of Shantou University,Shantou,Guangdong 515065,China  
Objective To evaluate the efficacy of oxymatrine in treating chronic hepatitis C and its mechanism.Methods Forty three patient were divided randomly into the treated group(20 cases)and the control group(23 cases).The treated gruop was given oxymatrine 600 my per day intramuscularly,and the control group was given the general liver protective agents such as vitamins.The therapeutic course of bot groups was 3 mouths.Results HCV RNA of 8 in 17 case(47.1%)of the treated group converted to negative,while in 18 cases of the control group,the negative conversion only took place in 1 patient(5.6%),the negative conversion rate was significantly higher in the treated group than that in the control group(P0.05).The normalizaton rates of serum alanine transaminase(ALT)of the greated group after 1 month and 2 months treatment was higher than that of the control group,but after 3 months treatment,the normalization rates of the two groups were not different significantly.Plasma level of soluble interleukin-2 receptor and serum level of collagen type IV in the treated group were lowered significantly after treatment ,but in the control group,there were no significant change,the difference between the two groups was significant(P0.01,P0.05).Conclusion Oxymatrine is effective in inhibiting proliferation of HCV.an tagonisting liver fibrosis and regulating immune reaction of the host,so it could be a safe,effective durg in treating chronic hepatitis C.
【CateGory Index】: R259
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