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《Sichuan Medical Journal》 2007-10
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Effect of Quercetin on the expression and growth of Bcl-2 in lung adenocarcinoma cancer cell line A549.

Zhang Yonggang,Zhang Jie,Fan Hong,et al.Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China  
Objective To study the influence of Quercetin on the expression of Bcl-2 in lung adenocarcinoma cancer cell line A549.Methods The mRNA expression of Bcl-2 in A549 cells was detected by RT-PCR,and the protein expression was detected by Western blot.Results The mRNA and protein expressions of Bcl-2 were inhibited by Quercetin in a dose-and timedependent way.Conclusion The inhibitory effect of Quercetin on Bcl-2 in A549 cells may provide a theoretic basis on future therapy of tumor.
【Fund】: 国家自然科学基金(批准号:30470761);; 中国博士后科学基金(批准号:2005038268)
【CateGory Index】: R734.2
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【References】
Chinese Journal Full-text Database 1 Hits
1 YANG Chao-hua,LI Guo-ping,YOU Chao,et al.Department of Neurosurgery,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China;Effect of phenylacetate on the expression of Bcl-2,Bax and Caspase-3 in rat C6 glioma cells[J];Sichuan Medical Journal;2008-08
【Citations】
Chinese Journal Full-text Database 10 Hits
1 ZHOU Li-xiang,LUO Yi-nan~,FU Shuang-lin,GE Peng-fei,ZHUANG Han-ting(Department of Neurosurgery,First Hospital,Jilin University,Changchun 130021,China);Effect of quercetin on proliferation of rat glioma C6 cells[J];Journal of Jilin University(Medicine Edition);2006-02
2 XIANG Ting-xiu,TAO Xiao-hong,JIANG Zheng,WANG Pi-long(Department of Digestion,First Affiliated Hospital, Chongqing University of Medical Sciences,Chongqing 400016,China);Effects of quercetin on proliferation of gastric cancer lines BGC823 and the expression of p53,Bcl-2/Bax and PCNA[J];Laser Journal;2006-01
3 ZHU Yan ping 1 , JIN Nian zu 1 , ZHOU Jian wei 1 , MAO Li 1 , ZHAO Ren zheng 1 , TONG Jian 2 (1. The School of Public Health , Nanjing Medical University, Nanjing 210029,Jiangsu,China; 2. School of Nuclear Medicine, Suzhou University, Suzhou 215007,Jiangsu,China);The potential mechanism of quercetin on apoptosis induction in mice melanoma Cloundman S91 cells[J];Journal of Medical Postgraduates;2003-12
4 Tang Qing,Yang Ping,Zhu Tianyi.The occupational and technological college of Liaoning traditional chinese medical university,ShenYang,110101;Influence of quercetin(Qu) on hepatocarcinogenesis induced by DEN in rats[J];Medical Journal of Liaoning;2006-01
5 WANG Hai-yan, GUO Liang-miao, CHEN Yong, ZHAO Xue-hua, CHENG Cai-lian, WU Mian-yun, HE Li-ya * Institute of Cellular and Molecular Biology, College of Medical Science, Wuhan University of Science and Technology, Wuhan 430080, China;Quercetin inhibits growth and induces apoptosis of human gastric carcinoma cells[J];Chinese Journal of Cellular and Molecular Immunology;2006-05
6 Xin-Yun Yan, Zhao Tao, Department of Gastroenterology, Lanlian Hospital, Lanzhou Petrochemical Industry Corporation, LanZhou 730060, Gansu Province, China Jun-Hua Peng, Hua-Xin Zhang, Feng-Zhang, Department of Clinical Laboratory, Lanzhou General Hospital, Lanzhou Military Command of Chinese PLA, Lanzhou 730050, Gansu Province, China Xiao-Hong Bian, Department of Digestive Diseases, Lanzhou General Hospital, Lanzhou Military Command of Chinese PLA, Lanzhou 730050, Gansu Province, China Hai-Zhong Wang, Tumor Department of Lanzhou General Hospital, Lanzhou Military Command of Chinese PLA, Lanzhou 730050, Gansu Province, China;Effects of quercetin on proliferation and cell cycle of colon carcinoma cell Line HT-29[J];World Chinese Journal of Digestology;2006-11
7 LI Yan Song, KANG Tie Bang, LIANG Nian Ci (Dept of Pathology, The Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001);Effect of quercetin of the expressions of p53 and bcl 2 gene proteins in intact HL 60 cells[J];CHINESE PHARMACOLOGICAL BULLETIN;1999-03
8 WANG Haiyan,GUO Liangmiao,CHEN Yong,ZHAO Xuehua,CHENG Cailian,WU Mianyun,HE Liya(College of Medical Science,Wuhan University of Science and Technology,Wuhan 430080,China);Study on Growth Effect and Apoptosis Action of Quercetin on Human Gastric Carcinoma Cells MGC-803[J];China Pharmacy;2006-19
9 Zhang Jie Lü Cai Zhang Ping-an et al Department of Urology, People's Hospital of Wuhan University, Wuhan;Empirical Studies on Quercetin for Inhibition of Proliferation ofhuman Uterine Cervix Cancer HeLa cells[J];Chinese Journal of Clinical Oncology;2006-08
10 LIN Hui *, WU Kai nan, KONG Ling quan. *Department of General Surgery, The Xiangtan Center Hospital of Hunan Province, Xiangtan 411200;STUDY ON THE INHIBITORY EFFECTS OF QUERCETIN ON THE OCCURRENCE AND PROLIFERATION OF EXPERIMENTAL MAMMARY CARCINOMA[J];Chinese Journal of Bases and Clincs In General Surgery;2001-05
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHU Zhan-peng1,KANG Jin-song2,KONG Xiao-xia2,LUO Yi-nan1,SUN Lian-kun2(1.Department of Neurosurgery,First Hospital,Jilin University,Changchun 130021,China; 2.Department of Pathophysiology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China);Effects of OHAP-1 on expression of bcl-2/bax mRNA and oxidative stress in rat C6 glioma cells[J];Journal of Jilin University(Medicine Edition);2007-04
2 QIU Ji-qing,ZHU Zhan-peng,LI Run-bo,LIU Xing-ji,YU Hong-quan,ZHAO Gang(Department of Neurosurgery,First Hospital,Jilin University,Changchun 130021,China);Expression of PTEN mRNA in human brain glioma tissue and its SSCP analysis of gene mutation[J];Journal of Jilin University(Medicine Edition);2008-03
3 ZHANG Yong-li1,ZHAN Miao1,PAN Yu-fang2,FAN Wei3,LI Hong-zhi1,HUANG Qing-song1(1.Section of Medical biology,Department of Biology,School of Basic courses,Guangdong Pharmaceutical University,Guangzhou 510006,China; 2.School of Continuing education,Guangdong Pharmaceutical University,Guangzhou 510224,China; 3.Affiliated Tumour Hospital of Guangzhou Medical College,Guangzhou 510095,China);Study on the contribution to the cytokines of the carya bark decoction to the BALb/c tumor-bearing mice[J];Strait Pharmaceutical Journal;2009-06
4 REN Yi-jun,GE Chang-zheng,GAO Feng-xi The Affiliated Jingzhou Hospital,Tongji Medical College of Central China Technology University,Jingzhou,Hunan,China,434020;Progress in the Treatment of Cancer of Larynx With Chinese Herbs[J];Guiding Journal of Traditional Chinese Medicine and Pharmacy;2009-07
5 Zhong Xiaogang *, Wu Kainan, He Sheng, Ma Shuangwei, Kong Lingquan. *Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China;Effects of Quercetin on the Proliferation and Apoptosis in Transplantation Tumor of Breast Cancer in Nude Mice[J];Journal of Sichuan University (Medical Sciences Edition);2003-03
6 JIN Nian-zu 1, MAO Li 1, ZHU Yan-ping 1, ZHAO Ren-cheng 1,ZHAO Hong-yan 1, YU Jing 1, CHEN Jing-heng 1, FANG Tai-hui 2(1. School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu,China ; 2. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu,China );The inhibition effects and mechanism of quercetin on proliferation of lung carcinoma cell and implanted Lewis lung carcinoma in mice[J];Journal of Medical Postgraduates;2005-02
7 ZHANG Yirong1 LI Yeping1(1Department of Urology,First Affiliated Hospital of Wenzhou Medical College,Zhejiang,Wenzhou,325000,China);Effects of quercetin on human bladder cancer cell line EJ[J];Journal of Clinical Urology;2007-08
8 WANG Yan,CHANGJie,XUFeng,CHENG Hua,CHENG Shuiyuan(1 Yangtze University School of landscape gardening,Jingzhou 434025,China;2 Huanggang Teachers College of Life Science and Engineering,Huanggang 438000,China);Research Progress of Flavonoids in Juglandaceae[J];Modern Agricultural Sciences;2008-11
9 HUANG Jing,ZHANG Wei,LI Fumin,LI DanDept.of Gynecology and Obstetrics,Renmin Hospital of Wuhan University,Wuhan 430060,China;Effect of Quercetin on the Expression of Nm23 Gene in HeLa cells[J];Medical Journal of Wuhan University;2009-05
10 LiXianhui1,Hu Xiqi2,Long Ying2,Cao Ping2,Zheng Yaofan2,Li Zhang Jie2 1Staff room of function,Medicine of China Jishou University,416000,Jishou Hunan,China;2Medicine Department clinical class 1 grade 2006 of Jishou University,416000 Jishou Hunan,China;Effect of the herb serume containing VDG on proliferation and apoptosis of K562 leukemia cell[J];Chinese Journal of Ethnomedicine and Ethnopharmacy;2009-15
【Co-references】
Chinese Journal Full-text Database 9 Hits
1 DU Hua (Laboratory of Nuclear Analysis Techniques,Institute of High Energy Physic s,Chinese Academy of Sciences,Beijing100039,China);The regulating mechanism of p53during cell cycle arrest and apoptosis[J];Foreign Medical Science.radiomedicine and Nuclear Medicine;2002-02
2 NIU Pi-ye,GONG Zhi-yong,TAN Hao,WANG Feng,ZOU Yun-feng,YANG Jin,DUAN Yan-ying,YUAN Jing,WU Tang-chun(School of Public Health,Tongji Medical College,Huazhong University ofScience & Technology,Wuhan Hubei 430030 China);Study on DNA Damage Caused by Ultraviolet C Irradiation in A549 Cells Inhibited HSP70 Expression[J];Industrial Health and Occupational Diseases;2007-02
3 LI Guang-cheng,DONG Ke-li, HU Can-hong(Department of Traditional Chinese Medicine, Third Xiangya Hospital, Central South Universty, Changsha 410003, China);Effect of compound Rhizoma Smilacinus granules on the expression of Bcl-2 and Bax gene in A549 cell lines of non-small cell lung cancers[J];Journal of Central South University(Medical Sciences);2007-02
4 Zheng Yongtang & Ben Kunlong (Kunming Institute of Zooloy,Academia Sinica, Kunming 650107);Use of MTT Assay for the Determination of Cell Viability and Proliferation[J];Immunological Journal;1992-04
5 Xiao Dangl;Gu Zhenlun (Department of Pharmacology,Suzhou Medical College );Effects of Quercetin on Intracellular Free Calcium Concentration Induced by Thrombin in Human[J];ACTA ACADEMIAE MEDICINAE SUZHOU;1995-01
6 ;Research of quercetin on Antitumour activit[J];Journal of Modern Clinical Medical Bioengineering;2005-01
7 ZHU Lei, HE Li-ya (College of Medical Science,Wuhan University of Science and Technology,Wuhan 430080,China);Molecular Mechanism of Antitumor Action of Quercetin[J];Journal of Wuhan Yejin University of Science and Technology;2004-02
8 Zhou Yongqi 1, Deng Xiangping 2, Gu Zhenlun 2 (1.The First Hospital of Taicang, Taicang 215400;2.The Pharmacology Department of Medical College in Suzhou University, Suzhou 215007);The Effects of Huperzine-A on Oxygen-derived Free Radicals[J];Chinese Wild Plant Resources;2004-02
9 Xiao Dong,Gu Zhenlun Antitumor activity of quercetin and tumor related messenger RNA expression Χiao Dong,Gu Zhenlun,Zhu Shoupeng (Suzhou Medical College,Suzhou 215007);Antitumor Activity of Quercetin and Tumor-related Messenger RNA Expression[J];CHINESE WILD PLANT RESOURCES;1996-04
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 YAO Lu yu, HONG Min , LIU Chang (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Jilin University, Changchun 130021, China);Effects of morphine on P53 and Bcl-2 protein levels in C6 glioma cells in rats[J];Journal of Jilin University of (Medicine Edition);2004-03
2 HAN Xue mei 1,XIONG Wen ji 2,HU Guo zhong 3 (1. Department of Neurology, China Japan Union Hospital,Jilin University,Changchun 130031,China; 2. Department of Cadre Ward, First Hospital,Jilin University,Changchun 130021,China; 3. Department of Prevention and Health Pharmacy,China Japan Union Hospital,Changchun 130021,China);Effects of Ginaton on expressions of Fas and Bcl-2 protein in rats with cerebral ischemia reperfusion injury[J];Journal of Jilin University of (Medicine Edition);2004-03
3 LUO Jin-yong , LI Lin, YIN Yi-bing (Department of Diagnosis Laboratory,Chongqing University of Medical Science,Chongqing 400016,China);The effect of quercetin on proliferation and apoptosis of A549 lung cancer cell[J];Chongqing Medical Journal;2005-04
4 WANG Bin, MI Man-tian, PENG Jun-hua, ZHU Jun-dong (Department of Nutrition and Food Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China);Effects of octylphenol and genistein on the incidence and proliferation of breast cancer[J];Acta Academiae Medicinae Militaris Tertiae;2005-02
5 GAO Jin-li,JIN Ke-wei,GAO Qian( Department of Pathology, Kunming Medical College, Kunming 650031);The Expression of Bc1-2 Protein in Lung Carcinoma Tissues[J];Academic Journal of Kunming Medical College;2001-03
6 XIE Qing wen, ZHAO Jing qiu, FANG Zhi wen (Department of Hematology, Shanghai Railway Central Hosipital, Shanghai 200070, China);The Effect of Quercetin Targeted p53 Gene and Protein Expression in NB4 Cell Lines[J];Acta Universitatis Medicinalis Secondae Shanghai;2001-01
7 ZHONG Lu,CHEN Fangyuan, HAN Jieying, et al. Shanghai Institute of Hematology, Renji Hospital. Shanghai Second Medical University,Shanghai 200001;Effects of quercetin on cell morphology and expression of PML mRNA and protein of NB4,HL-60 cells[J];Shanghai Medical Journal;2001-01
8 Gu Baoliang,Zou Wei,Zhang Yanfeng,et al Qingdao Cancer Hospital,Qingdao2 6 6 0 42;THE EXPRESSION OF APOPTOSIS-SUPPRESSING GENE bcl-2 IN L UNG CANCER AND ITSRELATIONSHIP WITH PROG-NOSIS[J];MEDICAL JOURNAL OF QILU;1998-03
9 XIANG Tingxiu,WANG Pilong,GAO Qing et alDepartment of Digestion,First Affiliated hospital,Chongqing University of Medicine,Chongqing 400016,China;Effects of quercetin on proliferation of gastric cancer lines SGC-7901 and BGC-823[J];Chinese Journal of Gastroenterology and Hepatology;2003-06
10 Ma Dongchun, Shu Yuanshan,Wei Dazhong, et al(Dept of thoracoardiac surgery. Anhui Provincial Hosptial, Hefei 230001);A Study on the Expression Apoptosis-Suppressing Gene bcl-2 Product in Lung Cancer[J];Acta Academiae Medicinae Wannan;2001-01
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