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《Sichuan Medical Journal》 2009-12
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Expression of phosphorylate-p38 mitogen-activated protein kinase in skin squamous cell carcinoma and its significance

LU Mao,YE Jun-ru,FAN Yuan-chun,et al.The First Affiliated Hospital of Chengdu Medical College,Chengdu,Sichuan 610500,China  
Ojbective To investigate the expression of phosphorylated-p38 mitogen-activated protein kinase(p-p38 MAPK)and its significance in skin squamous cell carcinoma(SCC).Methods Immunohistochemistry SP method was used to detect the expression of p-p38 MAPK in specimens from 60 cases of skin SCC.Results The expression of p-p38 MAPK was mainly localized in the cell nucleus.Positive rate of p-p38 MAPK expression in skin SCC was significantly higher than that in normal skin.The expression of p-p38 MAPK was correlated with histology grade,tumor size and lymph node metastasis,but not with age or gender.Conclusion Overexpression of p-p38 MAPK may be related to the occurrence and development of skin SCC.
【CateGory Index】: R739.5
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