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《Sichuan Medical Journal》 2012-04
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The relationship between the expression of AQP4 and clinical outcomes of head-injured patients

OUYANG Xi-hua,JIA Jun,LIU Zheng-wei.Longgang Central Hospital of Shenzhen,Shenzhen,Guangdong 518116,China  
Objective To contrast the different expression of water channel protein 4(AQP4) in different degree of head-injured patients,to discuss the relationship between the AQP4 and clinical outcomes.Methods According to the GCS score,87 cases of head-injured patients was divided into three groups,moderate damage group(GCS 9~12points),severe damage group(GCS 4~8 points) and especially severe damage group(GCS 3 points).To detect the expression of AQP4 in with different groups of brain trauma area specimens by immunohistoche-mical method.Results ①The brain cells and endothelial cells mild swelling in moderate brain injury group;and the brain cells swelling obvious,endothelial cells swelling obvious,perivascular gap significantly increased,and the blood brain barrier severely damaged in the severe and especially severe brain trauma group.②The tan dyeing in the brain tissue cell membrane or cell plasma was defined as AQP4 positive expression.Along with the damage degree aggravating,the express of AQP4 was increasing.The expression in especially severe damage was the strongest,followed by severe damage group,moderate damage group,and the difference was statistical significance(P0.05).Conclusion Threr are the positive correlation between the expression of AQP4 and disease degree,which could point out the patient prognosis.And restraining the activity of AQP4 may reducecerebral edema,improve the prognosis.
【CateGory Index】: R651.15
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