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《Sichuan Medical Journal》 2014-07
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Relationship between the Severity of Kidney Damage and the Levels of Ang-1 and Ang-2 in Patient with Sepsis

Mai Zhenhua;Tong Lin;Zhong Xiuming;Affiliated Hospital of Guangdong Medical College;  
Objective To investigate the relationship between the severity of kidney damage and the level of Ang-1 and Ang-2 in patients with sepsis. Methods 96 septic patients admitted to ICU were divided into NAKI group( n = 46),AKIⅠgroup( n=23),AKIⅡ group( n=11),AKIⅢ group( n=16) according to different damage degrees under AKIN criteria,and 30healthy people were also enrolled as healthy control group( n = 30). The clinical data including the acute physiology and chronic healthy conditions( APACHE) Ⅱ score and sequential organ failure( SOFA) score were collected and recorded. Blood samples were collected to detect plasma Ang-1,Ang-2,Scr and Ccr and correlation was analyzed. Results ①The plasma Ang-1 levels in NAKI,AKIⅠ,AKIⅡ,AKIⅢ groups were significantly lower compared with CON group( P0. 01),but there were no difference among the four groups( P0. 05). The plasma Ang-2 levels in NAKI,AKIⅠ,AKIⅡ,AKIⅢ groups were significantly higher compared with CON group( P0. 01),and the plasma Ang-2 levels of the four groups significantly increased as their AKI classification increased. ②The plasma Ang-1 level and Ccr was not correlated( P0. 05). The plasma Ang-2 level and Ccr was significant correlated( P0. 01). Multiple linear regression analysis showed that plasma Ang-2 level was significantly independently correlated with Ccr( P0. 01). ③The plasma Ang-1 levels and the APACHEⅡ score and SOFA score were not correlated( P0.05). The plasma Ang-2 levels and the APACHEⅡ score and SOFA score was positively correlated( P0. 01). Multiple linear regression analysis showed that plasma Ang-2 level was significantly independently correlated with the APACHEⅡ score and SOFA score( P0. 05). Conclusion The plasma Ang-2 level is an independent risk factor associated with severity of kidney damage of septic patients.
【Fund】: 广东省医学科研基金(编号:A2009484);; 湛江市科技攻关计划项目(编号:2013B01038);; 广东医学院科研基金(编号:M2013028)
【CateGory Index】: R459.7
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