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《Sichuan Medical Journal》 2015-07
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The Study of the Ultrastructural changes of the Bile Duct Injury in the Obstructive Jaundice Experimental

Wang Li;Chen Zhang;Li Kun;Leshan People's Hospital;Chengdu Army General Hospital;  
Objective To study the histology and ultra-microscopic structural changes of reversible obstructive jaundice bile duct injury in animal model. Methods Reversible obstructive jaundice bile duct injury in experimental rabbits was created via clamping bile duct by astrictive clamps. From the third day to the 30 th day post biliary obstruction,the levels of serum bilirubin( TBIL,DBIL) and bile acid( BA) were detected and the pathological examination was made on the tissues of bile duct. Meanwhile,bile duct tissue specimens of bile duct were obtained on 14 th day post treatment and then observed under electronic microscope. Results On the 7th day post biliary obstruction,the TBIL、DBIL and BA experimental group were( 31. 1±16. 9) μmol / L,( 16. 70±9. 20) μmol/L and( 61. 5±24. 5) μmol/L,which are significantly higher than those( 5. 9±1. 5) μmol/L,( 1. 60±0. 58)μmol /L and( 21. 1±13. 5) μmol /L,( P0. 01) in the control group. The TBIL、DBIL、BA levels of rabbits in the experimental group were elevated in 30 days. From the third day to the 30 th day post biliary obstruction,the pathohistological examination of bile duct showed that,experimental group injury-related bile duct inflammation and induced bile duct obstruction,and biliary obstruction was partially recovered in 30 th day. Ultra-microscopic structural changes results illustrate that on 14 th day after biliary obstruction,obviously damnification were found in nucleus and organelles of bile duct layers of cells. Conclusion External force induced reversible obstructive jaundice can cause obvious changes in Histopathological examinations and ultra-microscopic structure of bile duct.
【CateGory Index】: R575
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