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《Sichuan Medical Journal》 2017-08
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Effects of Tanshinone on Bone Healing Indexes and Levels of Inflammatory Cytokines in Old Patients with Limbs Fracture

Huang Gang;People's Hospital of Baise;  
Objective To investigate the effects of using tanshinone as an adjuvant therapy after surgery on bone healing indexes and levels of inflammatory cytokines in old patients with limbs fracture.Methods 120 old patients with limbs fracture who were treated with open reduction and internal fixation were selected from January 2014 to April 2016.According to random numbers based on spss16. 0,they were equally divided into tanshinone group and control group.Both two groups were carried with open reduction and internal fixation and after surgery tanshinone injection was added in tanshinone group.Bone healing indexes and level of inflammatory cytokines of two groups were compared.Results Before treatment,there were no statistic difference in serum bone alkaline phosphatase( ALP),procollagen Ⅰcarboxy terminal peptide( PICP),procollagen Ⅰ carboxy terminal peptide sequence specific β( β-CTX),bone gla protein( BGP),C reactive protein( CRP) and interleukin-6( IL-6),IL-1,tumor necrosis factor α( TNF-α)( P0. 05).Three and seven days after treatment,tanshinone group had higher levels of ALP,PICP and BGP( P0. 05)and lower levels of CRP,IL-6,IL-1,TNF-α and β-CTX( P 0. 05). Before treatment,there were no statistic difference in VAS scores and swelling degree scores( P 0. 05). Three and seven days after treatment,tanshinone group had lower VAS scores and swelling degree scores( P0. 05). Conclusion Using tanshinone as an adjuvant therapy after surgery can improve bone metabolism indexes and reduce the inflammatory reaction and swelling pain degree in old patients with limbs fracture.
【CateGory Index】: R274.1
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