Effects of Hydroxycamptothecin Combined Chemotherapy in Advanced Digestive System Malignant Tumors
ZHANG ChuangDepartment of Medical Oncology,The Second Hospital of Huaian,Huaian 223002
Objective:To observe the efficacy and toxicity of hydroxycamptothecin(HCPT) combined chemotherapy in the treatment of the patients with digestive system malignant tumor. Methods: 49 cases with digestive system malignant tumor were treated with HCPT 6mg/m 2 /d iv gtt ,maintaining 4～6h,d1～10, combined with PLF,ELF,PPF,and PAF. Results:The total remission rate(CR+PR)was 53.1%,with CR 2 cases,PR 24 cases,NC 15 cases and PD 8 cases.The major toxicity were mild nausea, vomiting,neucopenia,nucositis and so on.Conclusion: HCPT was added to common chemothrapy in the treatment of advanced digestive system malignant tumor,this method is characterized by small toxicity,good toleration,and high efficacy.
【CateGory Index】： R730.5