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《Journal of Sichuan of Traditional Chinese Medicine》 2008-07
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Effects of Yifujuanbi Granule on the Contents of NO,TNFα and IL-1 in Serum of Rats with Adjuvant Arthritis

Dai Yuan1 Xu Shijun2 Peng Yuhua2//(1.Mianyang Central Hospital Mianyang 621000;2.Chengdu University of Traditional Chinese Medicine Chengdu 610075)  
Objective: To study the effects of Yifujuanbi Granule on the contents of nitric oxide(NO),tumor necrosis factor-α(TNFα) and interleukin-1(IL-1) in serum of rats with adjuvant arthritis.Methods: the RA model was established firstly.Then,the contents of NO,TNFα and IL-1 in rat serum were detected after the rats were treated with Yifujuanbi Granule.Results: The contents of NO,TNFα and IL-1 in the serum of rats with adjuvant arthritis were significantly higher than that of the model control group(RA group).The abnormal increase of NO,TNFα and IL-1 were inhibited markedly in the experimental groups.Conclusion: Yifujuanbi Granule can inhibit the increase of NO,TNFα and IL-1 in serum of rats with adjuvant arthritis.This inhibitory effect may be one of the mechanisms of Yifujuanbi Granule in treating rheumatoid arthritis.
【Fund】: 国家中医药管理局中医科技进步工程专项基金课题(06-07ZQ12);; 四川省中医药管理局重点课题(课题编号:2003A12)
【CateGory Index】: R285.5
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