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《Journal of Psychiatry》 2012-02
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Effect of oxiracetam adjunctive treatment with quetiapine on cognitive impairments in aged patients with schizophrenia

GU Pei,WANG Jing,LI Baozhou,et al.Tianjin Anding Hospital,Tianjin 300222,China  
Objective To study the efficacy of oxiracetam on cognitive impairment in aged schizophrenic patients.Methods A total of 48 aged patients with schizophrenia were randomly divided into study group treated with quetiapine combined with oxiracetam and control group treated with quetiapine monotherapy for 8 weeks.The cognitive function was assessed at baseline and at the 8th weekend.The clinical efficacy was evaluated with Positive and Negative Syndrome Scale(PANSS).Results At the 8th weekend,scores of cognitive test and PANSS were improved significantly compared with those at baseline(P0.05 or P0.01).Total score of visual reproduction subsets,digit span test,trail making test A and B in study group were significantly higher than those in control group(P0.05 or P0.01).Conclusion Oxiracetam could improve the the cognitive function of aged schizophrenic patients.
【CateGory Index】: R749.3
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 HU Maoron,CHEN Jindong,LI Lehua,GUO Xiaofeng,OU Jianjun,WANG Juan,ZHAO Jingping.Mental Health Institute of The Second Xiangya Hospital,Central South University,changsha Hunan 410011,china;Comparison of cognitive function in first-episode schizophrenia patients between baseline and after risperidone treatment[J];Journal of International Psychiatry;2010-03
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【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 ZHOU Fei,ZHU You-ling.(The First People's Hospital of Hefei,Anhui 230061,China);Oxiracetam combined with vinpocetine injection in treatment of mild cognitive impairment disorder of convalescent patients with cerebral infarct[J];Journal of Huaihai Medicine;2012-03
2 YAN Jun1,MENG Gen-Hua2,LI Gang3 1Peking University Institute of Mental Health,Key laboratory of Mental Health,Ministry of Health(Peking University),Beijing 100191,China 2Inner Mongolia Mental Health,Hohhot 010010,China 3Inner Mongolia ChiFeng Anding Hospital,Chifeng 024000,Inner Mongolia Autonomous Region,China;Executive function characteristics in patients with obsessive-compulsive disorder and patients with schizophrenia[J];Chinese Mental Health Journal;2012-01
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 WANG Hong-mei~*,GE Xu-hua,ZHOU Lian-sheng,GENG De-qin~*Department of Neurology,the First People's Hospital of Xuzhou,Xuzhou 221002,China;Clinical observation on safety and efficacy of donepezil in treating Alzheimer disease[J];Clinical Focus;2006-07
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3 HUA Jin-bao (Zhejiang Province Anji the Third People's Hospital,313301,China);Clinical observation on oxiracetam's effects on rehsbitation of cognitive function in patients of hypertensive cerebral hemorrhage[J];Chinese Journal of Hospital Pharmacy;2008-14
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