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《Journal of Psychiatry》 2012-02
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Effect of oxiracetam adjunctive treatment with quetiapine on cognitive impairments in aged patients with schizophrenia

GU Pei,WANG Jing,LI Baozhou,et al.Tianjin Anding Hospital,Tianjin 300222,China  
Objective To study the efficacy of oxiracetam on cognitive impairment in aged schizophrenic patients.Methods A total of 48 aged patients with schizophrenia were randomly divided into study group treated with quetiapine combined with oxiracetam and control group treated with quetiapine monotherapy for 8 weeks.The cognitive function was assessed at baseline and at the 8th weekend.The clinical efficacy was evaluated with Positive and Negative Syndrome Scale(PANSS).Results At the 8th weekend,scores of cognitive test and PANSS were improved significantly compared with those at baseline(P0.05 or P0.01).Total score of visual reproduction subsets,digit span test,trail making test A and B in study group were significantly higher than those in control group(P0.05 or P0.01).Conclusion Oxiracetam could improve the the cognitive function of aged schizophrenic patients.
【CateGory Index】: R749.3
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