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《Acta Academiae Medicinae Shandong》 2002-01
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Antioxidant effects of gypenosides on focal brain ischemia-reperfusion injury in rats

ZHANG Xiu-mei, CAO Xiao-qing,WEI Xin-bing,et al (Dept. of Pharmacology,School of Medicine, Shandong University)  
Objective:To investigate the antioxidant effects of gypenosides on cerebral ischemia reperfusion injury in rats.Methods: Malondialdehyde(MDA) and superoxide dismutase(SOD) levels in cerebral su bcellular organ of brain were meassured and ultrastructure was studied under transmission electronic microscope in a model of reversible middle cerebral artery occlusion(MCAO) without craniectomy.Results:MDA level increased and SOD level of brain decreased significantly in ischemia reperfusion injury group but through gypenosides treatment,MDA level decreased and SOD level increased significantly, and ultrastructure changes in CA1 region of hippocampus also improved.Conclusion:Gypenosides may play a role in the neuroprotection of cerebral ischmia reperfusion injury by decreasing the oxygen free radicals and increasing the activity of antioxidant enzyme in the body.
【Fund】: 山东省自然科学基金资助课题(Y95C1133)
【CateGory Index】: R285.5
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【Co-references】
Chinese Journal Full-text Database 7 Hits
1 WAN Li, WAN Xing-Wang, HU Jin-Hong (1. Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; 2. International Cooperation Laboratory of Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438);Effect of gypenosides on hepatic function and fibrosis in rats with immune fibrosis[J];Academic Journal of Second Military Medical University;2003-12
2 ZHANG Yong,DING Guohua,ZHANG Jiane,et alDivision of Nephrology,The Affiliated Renmin Hospital of Wuhan University,Wuhan (430060);Effect of Gypenosides on Expression of Connective Tissue Growth Factor(CTGF) in UUO Rats with Renal Tubulointerstitial Fibrosis[J];Chinese Journal of Integrated Traditional and Western Nephrology;2005-07
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5 Chen Jixiang,Zhang Jianguo,Zhang Li,Liu Jingbo (Beijing Pharmaceutical College,Beijing,China 100012);Study on Liver-protective Effect of Total Saponins of Gynostemma Pentaphyllum[J];China Pharmaceuticals;2007-13
6 LIN Chang zheng, CAO Yong xiao, LI Chang shun, LIU Jing (Xi'an Jiao tong University, Xi'an 710061, China);Protection of Pingkui Powder from acute gastric ulcer in rats[J];Chinese Traditional Patent Medicine;2004-02
7 Pan Jiahu,Zhou Yun,Yang Xiangnuan,et al.(Dept.of Pharmacology,School of Pharmacy,Shanghai Medical University,Shanghai 200032);Preventive Effects of Ganoderma Lucidum on the Radical Injury Induced by Adriamycin[J];PHARMACOLOGY AND CLINICS OF CHINESE MATERIA MEDICA;1998-02
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