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《Acta Academiae Medicinae Shandong》 2002-01
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Antioxidant effects of gypenosides on focal brain ischemia-reperfusion injury in rats

ZHANG Xiu-mei, CAO Xiao-qing,WEI Xin-bing,et al (Dept. of Pharmacology,School of Medicine, Shandong University)  
Objective:To investigate the antioxidant effects of gypenosides on cerebral ischemia reperfusion injury in rats.Methods: Malondialdehyde(MDA) and superoxide dismutase(SOD) levels in cerebral su bcellular organ of brain were meassured and ultrastructure was studied under transmission electronic microscope in a model of reversible middle cerebral artery occlusion(MCAO) without craniectomy.Results:MDA level increased and SOD level of brain decreased significantly in ischemia reperfusion injury group but through gypenosides treatment,MDA level decreased and SOD level increased significantly, and ultrastructure changes in CA1 region of hippocampus also improved.Conclusion:Gypenosides may play a role in the neuroprotection of cerebral ischmia reperfusion injury by decreasing the oxygen free radicals and increasing the activity of antioxidant enzyme in the body.
【Fund】: 山东省自然科学基金资助课题(Y95C1133)
【CateGory Index】: R285.5
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