Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Shandong Univenity(Health Scicnes)》 2005-10
Add to Favorite Get Latest Update

Protective effect of soy isoflavone on cognition disorder in Alzheimer's disease model rats

BI Jian-zhong1, CAO Li-jun1, XU Shun-liang1, WANG Shi-jun2, ZHOU Qing-bo1(1.Department of Neurology, Second Hospital of Shandong University, Jinan 250033, Shandong, China;2. Key Laboratory of Tumor Prevention and Treatment, Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong, China)  
Objective: To investigate the protection role of soy isoflavone on the learning deficiency induced by Aβ25~35 in rats. Methods: The model rat was made with Aβ25~35 stereotactic injection into bilateral hippocampus and the control rat was injected with normal saline in the same way. Soy isoflavone was administered with different dosage (25, 50 mg·kg-1 ) . Estradiol benzoate (1 mg·kg-1 ) was injected once every three days 24 hours after the injection of Aβ25~35 for 18 days. Morris water maze test was done at one week before animals were killed. Results: Aβ25~35 caused learning deficiency in rats. Administration of soy isoflavone could decrease the latency of escaping and increase the percentage of swimming distance in the platform quadrant and the number of entries in the target area. Isoflavone 50 mg·kg-1 group was better than isoflavone 25 mg·kg-1 group. Conclusion: Soy isoflavone can improve the learning and memory ability of AD model rats, this indicates primarily that soy isoflavone has the effect of anti-dementia.
【CateGory Index】: R285;
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 LI Hui(Department of Pharmaceutical Engineering,Wuhan Bioengineering Institute,Wuhan 430415,Hubei,China);Interventional Effects of Traditional Chinese Medicine and Acupuncture on Pathogeny of Alzheimer Disease[J];Journal of Wuhan Bioengineering Institute;2008-04
2 LI Hui(Pharmaceutical Department of Wuhan Bioengineering Institute,Wuhan 430415,China);Interventional effects of traditional Chinese medicine on Alzheimer disease[J];China Journal of Chinese Materia Medica;2008-21
Chinese Journal Full-text Database 1 Hits
1 ZHANG Xiao chun, ZUO Ping ping, GE Qin sheng * Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005 *Department of Obsterics & Gynecology, Peking Union Medical College Hospita;The effect of estrogen-like drug on the cognition of ovariectomized rats[J];Journal of Reproductive Medicine;2001-03
Chinese Journal Full-text Database 3 Hits
1 HONG Feng,XI Ceng-si (College of Life Sciences,Shaanxi Normal University,Xi'an,710062);The role of estrogen in the cognitive function of human beings[J];Progress in Modern Biomedicine;2006-09
2 ZUO Ping-ping, SUI Ya-ping, GE Qin-sheng * Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005 *Department of Obsterics & Gynecology, Peking Union Medical College Hospital, Beij;Effects of estrogen on the central nigral-striatal dopamine neuron system in ovariectomized rats[J];Journal of Reproductive Medicine;2002-03
3 ZHOU Lin~1,REN Mu-lan~(2*)1.Department of Obstetrics & Gynecology,Nanjing Maternity & Child Health Hospital,Nanjing 210004;2.Department of Obstetrics & Gynecology,Zhongda Hospital of Southeast University,Nanjing 210009;Effects of estrogen on β-amyloid protein(25~35)-induced apoptosis in rat cortical neurons[J];Journal of Reproductive Medicine;2006-05
Chinese Journal Full-text Database 10 Hits
1 ZHANG Kuihua, LAI Shilong, HU Jingqing, WANG QI, LIANG Weixiong, CHENG Shuyi (DME Center, Guangzhou University of TCM, Guangzhou 510405, China);Effects of Bushen Yizhi Decoction on Somatostatin-like Neurons in Hippocampal Gyrus of Rat Models with Alzheimer's Disease[J];Journal of Guangzhou University of Traditional Chinese Medicine;2001-01
2 LIU Bin, SHAO Hong, PENG Yongge, DING Huijing (Luohu District Hospital of TCM, Shenzhen 518001 Guangdong, China);A Survey and Analysis of Mild Cognitive Impairment in the Aged from Luohu District of Shenzhen City[J];Journal of Guangzhou University of Traditional Chinese Medicine;2005-05
3 WU Lei1,CHEN Yunbo2,WANG Qi2,CHENG Shuyi2,LIANG Weixiong2,WEN Zehuai2(1.The Second Affiliated Hospital,Guangzhou University of TCM,Guangzhou 510405,China;2.DME Center,Institute of Clinical Pharmacology,Guangzhou University of TCM,Guangzhou 510405,China);In-Vitro Inhibitory Effect of Ginsenoside Rg1 on Aβ_(25-35)-Induced NG108-15 Apoptosis in alzheimer's Disease Cellular model[J];Journal of Guangzhou University of Traditional Chinese Medicine;2007-02
4 Hao Jie,Yang Yun-xiaDepart ment of pharmacology,West-China Medical Center,Sichuan university Chengdu,China 610044;Effect of β-amyloid peptide in Alzheimer's disease[J];Sichuan Journal of Physiological Sciences;2007-02
5 Liu Zhen,Xiao Rong~(),Zhang Jie,Wu Huihui,Ye Xiaofang,Wen Juan(School of Public Health and Family Medicine,Capital University of Medical Sciences);Soybean Isoflavone Coordinated with Folic Acid Against the Damage Effect of Cyclophosphamide on Cultured Glial Cells[J];Journal of Capital University of Medical Sciences;2005-06
6 ZHU Jiaqi,TUO Xiping,JIA Liyan,ZHOU Jun.Department of Geriatrics,Changhai Hospital,Second Military Medical University, Shanghai 200433,China;Effect of Schisandrone on [Ca~(2+)]_i induced by amyloid-beta protein in cultured hippocampal neurons[J];Shanghai Medical Journal;2005-09
7 CAO Jianguo, HONG Tao, WEN Daxiang, GAO Yuan, WAN Yanjie, DIAO Shu, LI Lizhi, HANG Yannan, SUN Dajin. Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University, Shanghai 200001, China;Morbidity and related factors of postoperative mental and cognitive disorder in elderly patients[J];Shanghai Medical Journal;2005-11
8 JIANG Gui-mei~1,JIA Chao~2,LAI Xin-sheng~3.1.Department of Physiotherapy,Guangdong Hospital of Traditional Chinese Medicine,Guangzhou 510120,China;2.Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China;The Influence of Acupuncture on Neuron Apoptosis in a Rat Model of Alzheimer Disease[J];Shanghai Journal of Acupuncture and Moxibustion;2006-12
9 Lin Ji, Hou Shaozhen, LI Geng, ect(Guangzhou University of Traditional Chinese Medicine, Guangzhou, 510405);An Exploration on Adverse Reaction of Injection Puerarin and Exploitation of Oral Preparation of Puerarin[J];;2005-05
10 Yang Zhimin,Xie Dongping,Chen Shuhui,Ou Aihua,Lao Yingrong Guangdong Hospital of TCM, Guangzhou, Guangdong 510120,China;Primary investigation on the TCM syndrome distribution condition of the aged MCI[J];World Journal of Integrated Traditional and Western Medicine;2007-04
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 LIU Ben-juan,CAO Bao-ping,WU Min-yao(College of Life Science,Shanxi Normal University,Xi'an 710062,China);Progress in the research on neuroprotective effects of puerarin in the central nervous system[J];Chinese Bulletin of Life Sciences;2009-01
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Zhang Shi-yi, The Research Institute of Preclinical Medicine,The Chinese Academy of Medical Science, 100005;An animal model for cognitive deficit following brain damage[J];Chinese Journal of Rehabilitation Medicine;1993-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved