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《Journal of Shandong University(Health Sciences)》 2007-03
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Actovegin restores the digestive tract in rats with acute radiation enteritis

BI Ying-hui,HAN Jun-qing,SHENG Wei,LI Zhao-pei,HU Ping-ping,SHEN Bin(Tumor Research and Treatment Center,Shandong Provincial Hospital,Shandong University,Jinan 250021,Shandong,China)  
Objective:To evaluate the effect of Actovegin in restoring the digestive tract in rats with acute radiation enteritis.Methods: Whole abdominal radiation was performed on Wistar rats.The rats were randomly divided into three groups: the Actovegin group(Actovegin injection),the control group(irradiation only),and the normal group(without irradiation).Morphologic indices were measured by using light microscopy and the image analysis system.Intestinal NO concentration was detected by nitric acid reductase and bacterial translocation was also examined.Results: The Actovegin group had a significantly higher level of the height of the villus,the depth of crypt,the thickness of the mucosa and the entire wall,the number of the metaphase mitoses per crypt,and a significantly lower level of bacterial translocation and NO concentration compared with the control group.Conclusion: Actovegin accelerates recovery of injured digestive mucosal epithelium and decreases intestinal NO concentration and is good for regaining normal structure and function of digestive mucosa.
【CateGory Index】: R818.71
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