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《Journal of Shandong University(Health Sciences)》 2008-05
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Protective effects of gypenosides against glutamate-induced hippocampus injury in rats

HAN Yu-xia1,WEI Xin-bing1,LI Xia2,DING Yan1,XIN Hua2,DING Hua1 (1.Institute of Pharmacology,School of Medicine,Shangdong University,Jinan 250012,China;2.Institute of Cell Biology,School of Medicine,Shangdong University,Jinan 250012,China)  
Objective To investigate the protective effects of gypenosides(GP) against glutamate-induced oxidative injury to the hippocampus of rats.Methods 60 Wistar rats were randomly divided into 5 groups: the sham-operation group,the glutamate-induced injury group,the GP low(200 mg/kg),medium(400 mg/kg) and high(800 mg/kg) dose groups.Intra-gastric administration of GP was used for 10 d.2 h after injection with glutamate through the lateral ventricle,the homogenate of the hippocampus was collected and the MDA,SOD,GSH-Px activity and the hydroxyl radical generation capacity were determined.Results: The MDA concentration and hydroxyl radical generation capacity were significantly increased(P0.05),however activities of SOD and GSH-Px were significantly decreased(P0.01)in the glutamate-induced injury group compared with the sham-operation group.Also, the MDA concentration and hydroxyl radical generation capacity were significantly decreased in the GP groups compared with the glutamate-induced injury group (P0.01),and activities of SOD and GSH-Px were significantly increased(P0.01) by GP treatments,and 400 mg/kg GP had the most effective action.Conclusion The protective effects of GP against Glu-mediated nerve injury may be mediated by increasing the activity of antioxidant enzymes and inhibiting the hydroxyl radical production.
【Fund】: 山东省自然科学基金资助课题(Y2006C41)
【CateGory Index】: R285.5
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 XIN Hua, SHANG Lin-shan, LIU Jin-Cheng, et al(Institute of Cell Biology, School of Medicine, Shandong University, Jinan 250012, Shandong, China);Protective effects of gypenoside against oxidative neurotoxicity induced by glutamate[J];Journal of Shandong Univenity(Health Scicnes);2004-06
2 WANG Xu-ping,ZHAO Ling,FENG Yu-xin,SHANG Lin-shan,LIU Jin-cheng,CAO Wei-peng,ZHU Xiao-yin,XIN Hua(Institute of Cell Biology,School of Medicine,Shandong University,Jinan 250012,Shandong,China);Protection of gypenoside on glutamate-induced oxidation in the cultured cortical neurons of embryonic rats[J];Journal of Shandong University(Health Sciences);2006-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LI Ying,WANG Jing-zhou(Department of Neurology,Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing 400042,China);Combination of human cord blood stem cells transplantion into hippocampus CA1 area and intraperitoneal injection of monosialoganglioside treats vascular dementia rats[J];Acta Academiae Medicinae Militaris Tertiae;2008-12
2 YU Hong-rong,WANG Wei,GUO Ling,ZHANG Fang,LAN Lin,BEI LU.Department of Anatomy,Guangxi Medical University,Nanning 530021 China;Effect of melatonin on learning and memory as well as cell apoptosis and Box or Bcl-2 protein expression in the hippocampal dentate gyrus of rat with type 1 diabetic encophalopathy[J];Anatomy Research;2009-02
3 HU Zi-you1,QI Song-tao2,ZHANG Xia3,CAO Qiong1,WU Bing-yi1 1Research Center of Clinical Medicine,2Department of Neurosurgery,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;3Institute of Mental Health Research,University of Ottawa,Ottawa,Canada;Construction of δ-pIRES2-EGFP plasmid and its expression in HEK293 cells[J];Journal of Southern Medical University;2009-07
4 ZHAO Fengchen1),GUO Hua2),GAO Xiaoqun2),ZHANG Hua2)1)Department of Anatomy,Department of Basic Medical Sciences,Zhengzhou Railway Vocational and Technical College,Zhengzhou 450052 2)Department of Anatomy,College of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001;Fibrous connections between the gigantocellular reticular nucleus and the motor nucleus of cranial nerves that control the oculomotor muscles in the rat[J];Journal of Zhengzhou University(Medical Sciences);2007-05
5 WU Hai-qin,WANG Hu-qing,GUO He-na,ZHANG Ru,ZHANG Gui-lian. Department of Neurology,Second Affiliated Hospital of Medical College of Xi'an Jiaotong University,Xi'an 710004,China;Hypoxia Inducible Factor-1α Expression Trends in Hippocampus of Rat of Different Ages[J];Journal of Sichuan University(Medical Science Edition);2009-01
6 Yin Xiaolei,Yuan Rongdi,Ye Jian.Department of Ophthalmology,Daping Hospital,Third Military Medical University,Chongqing 400042,China;Influence of optic nerve transection on the expression of Nogo A/B and NgR in hypothalamic supraoptic nucleus neurocytes of rats[J];Medical Journal of Chinese People's Liberation Army;2008-09
7 GUO Xi-liang1),WANG Zhao-jun1) ZHU Xing-bao2),FENG Zhong-tang1),WANG Ting-hua1)(1) Institute of Neuroscience,Kunming Medical University,Kunming Yunnan 650031;2) Dept.of Neurosurgery,Kunming General Hospital of PLA,Kunming Yunnan 650032,China);Research Report of Tracing Corticospinal Tract in Rat with Biotinylated Dextran Amine[J];Journal of Kunming Medical University;2008-06
8 XU Zhuan~1 KONG Yan~1 DONG Wan-Li~1 CAO Bi-Yin~2 LIU Chun-Feng~2 1 Department of Neurology,First Affiliated Hospital,Soochow University,Suzhou 215006; 2 Department of Neurology,Second Affiliated Hospital,Soochow University,Suzhou 215004,China;Comparison on the Morphology of the Organotypic Brain Slice Culture in Vitro of Substantia Nigra and in Vivo[J];Chinese Journal of Clinical Neurosciences;2008-03
9 FAN Hong~1 SHAO Bei~1 WANG Hong~1 LIN Yuan-Shao~1 WAN Li~2 NI Gui-Hua~3 1 Department of Cerebrovascular Disease, 2 pathology Department,the First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000; 3 Department of Neurology,No.1 People' s Hospital of Huaian,Huaian 223000,China;Effect of Estrogen on the c-fos Expression in the Locus Ceruleus of Rat of Poststroke Depression[J];Chinese Journal of Clinical Neurosciences;2008-03
10 SUN Na,ZHAO Xia,LIU Jiang,et al(Department of Physiology,North China Coal Medical University,Tangshan 063000,China);The study on the dependablity between the electric stimulus of the dorsal motor nucleus of the vagus and myoelectric activity in the small intestine in rats[J];Journal of North China Coal Medical University;2009-04
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Chen Qianfen;Tian Hecun;Zhang Chenyin;Chu Dekai;Yang Weidong(Department of Pathophysilolgy,Bengbu Medical College,Anhui 233003);Protective effect of gypenosides on global cerebral ischemia-reperfusion injury in rat[J];ACTA ACADEMIAE MEDICINAE BENGBU;1996-06
2 Chi Mingyu Mei Xuewen Zheng Guiyuan Zhang Chengbo Hou Qinghua Han ChunlinNational Thrombus Disease Center of TCM Treatment,Shenyang 110101;PROTECTION OF JIAOGULANDAN ON THE MOUSE BRAIN WITHFOCAL CEREBRAL ISCHEMIA REPERFUSION INJURY[J];Guangxi Journal of Traditional Chinese Medicine;2003-04
3 Zhang Xiaoli Liu Zhen Zhu Ziping Yang Puzhao Xie Renming (Department of Pharmacology, Shanxi Academy of Traditional Chinese Medicine Xi'an 71003);INFLUENCE OF GYPENOSIDES ON THROMBUS AND COAGULATION FUNCTION IN VIVO AND IN VITRO[J];WEST CHINA JOURNAL OF PHARMACEUTCAL SCIENCES;1999-Z1
4 TANG Xiao-qing,ZHU Bing-yang,CHEN Jian-xiong,et al (Institute of Pharmacy & Pharmacology,Nanhua University,Hengyang,Hunan 421001,China) [WT5HZ];Protective Effect of Gypenosides on Ischemic Brain Damage Induced by Photochemistry[J];Journal of Hengyang Medical College;2001-02
5 Song Yuetao , Tang Yipeng, Hong Qingtao (College of Basic Medical Sciences, Beijing University of Traditional Chinese Medicine, Beijing 100029);Protective Effects of Kangdai I on the Cultivated Rat Cortical Neurons Damaged by Mimic Cerebral Ischemia and Reperfusion[J];Journal of Beijing University of Traditional Chinese Medicine;2004-02
6 ZHANG Xiu-mei, CAO Xiao-qing,WEI Xin-bing,et al (Dept. of Pharmacology,School of Medicine, Shandong University);Antioxidant effects of gypenosides on focal brain ischemia-reperfusion injury in rats[J];Acta Academiae Medicinae Shandong;2002-01
7 XIN Hua, SHANG Lin-shan, LIU Jin-Cheng, et al(Institute of Cell Biology, School of Medicine, Shandong University, Jinan 250012, Shandong, China);Protective effects of gypenoside against oxidative neurotoxicity induced by glutamate[J];Journal of Shandong Univenity(Health Scicnes);2004-06
8 Ma Xingfu, et al(Department of Pharmacology);THE ULTRASTRUCTURE STUDY ON EFFECTS OF GYPENOSIDES ON PLATELET FUNCTION IN RABBITS[J];Journal of Xi'an Jiaotong University(Medical Sciences);1988-04
9 Zhu Bingyang(Zhu BY),Tang Xiaoqing(Tang XQ),Huang Honglin(Huang HL),et al(Division of Cardiopulmonary Pharmacology, Hengyang Medical College,Hengyang 421001);Protective effect of gypenosides on brain ischemia induced by photochemical occlusion of middle cerebral artery in rats[J];Chinese Journal of Modern Applied Pharmacy;2001-01
10 WU Ji-Liang,QIU Pei-Lun,LIU Jun-Tian,MU Qi-Yun,XIN Dong-Sheng (Dept Pharmacology,Xian Medical University,Xian 710061);Effects of gypenosides on platelet aggregation release and cAMP level in rabbits[J];Chinese Journal of Pharmacology and Toxicology;1990-01
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