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《Journal of Shandong University(Health Sciences)》 2008-05
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Protective effects of gypenosides against glutamate-induced hippocampus injury in rats

HAN Yu-xia1,WEI Xin-bing1,LI Xia2,DING Yan1,XIN Hua2,DING Hua1 (1.Institute of Pharmacology,School of Medicine,Shangdong University,Jinan 250012,China;2.Institute of Cell Biology,School of Medicine,Shangdong University,Jinan 250012,China)  
Objective To investigate the protective effects of gypenosides(GP) against glutamate-induced oxidative injury to the hippocampus of rats.Methods 60 Wistar rats were randomly divided into 5 groups: the sham-operation group,the glutamate-induced injury group,the GP low(200 mg/kg),medium(400 mg/kg) and high(800 mg/kg) dose groups.Intra-gastric administration of GP was used for 10 d.2 h after injection with glutamate through the lateral ventricle,the homogenate of the hippocampus was collected and the MDA,SOD,GSH-Px activity and the hydroxyl radical generation capacity were determined.Results: The MDA concentration and hydroxyl radical generation capacity were significantly increased(P0.05),however activities of SOD and GSH-Px were significantly decreased(P0.01)in the glutamate-induced injury group compared with the sham-operation group.Also, the MDA concentration and hydroxyl radical generation capacity were significantly decreased in the GP groups compared with the glutamate-induced injury group (P0.01),and activities of SOD and GSH-Px were significantly increased(P0.01) by GP treatments,and 400 mg/kg GP had the most effective action.Conclusion The protective effects of GP against Glu-mediated nerve injury may be mediated by increasing the activity of antioxidant enzymes and inhibiting the hydroxyl radical production.
【Fund】: 山东省自然科学基金资助课题(Y2006C41)
【CateGory Index】: R285.5
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