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《Journal of Shandong University(Health Sciences)》 2009-05
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Effect of emodin on expression of ICAM-1 in the corneas of acute keratitis

CHEN Guo-ling1,2,CHEN Shuang3,XIAO Ying2,MAO Shu-zhi2,GAO Xue2,LIU Zhi-yu1 (1.Department of Anatomy,School of Medicine,Shandong University,Jinan 250012,China; 2.Ophthalmic Center of Shandong University,Department of Ophthalmology,Second Hospital of Shandong University,Jinan 250033,China;3.People′s Hospital of Shanting District,Zaozhuang 277200,Shandong,China)  
Objective To investigate the signification and effect of emodin on expression of intercellular adhesion molecule-1(ICAM-1) in the corneas of acute keratitis-induced by lipopolysaccharide(LPS) in Wistar rats.Methods Pseudomonas aeruginosa LPS-induced keratitis models were established in Wistar rats.Thirty minutes before LPS exposure,emodin and its vehicle were separately injected into sub-conjunctival tissues in Wistar rats.At 1,3,6,12 and 24 hours after being challenged with LPS,signs of both groups were observed,and severity of rats′ ocular inflammation was examined with a slit lamp microscope.The aqueous humor of each group was extracted and examined with hematoxylin and eosin(HE)-stained, and expression of ICAM-1 mRAN was detected by reverse transcriptase-polymerase chain reaction(RT-PCR).Results Ocular behavior was improved in rats which had undergone sub-conjunctival injection with emodin before being challenged with LPS.Inflammatory cells of the cornea and aqueous humor were less in rats of the treatment group than those of the inflammation group.The corneal edema and collagen fibers which appeared in disarrangement were also improved after emodin treatment.Expression of ICAM-1 mRNA of the treatment group was increased in each point after being challenged with LPS(P0.01),which was significantly inhibited by pre-treatment with emodin(P0.01).Conclusion Emodin can decrease expression of ICAM-1mRNA induced by LPS in the corneas of rats,and protects against acute corneal injury and improves rats′ symptoms.
【Fund】: 山东省教育厅科技计划项目(J08LH59)
【CateGory Index】: R285.5
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【References】
Chinese Journal Full-text Database 3 Hits
1 Shen Aijuan;Cai Wanru;The Second Clinical Medical College of Zhejiang TCM University;;The Research Progress on Anti-inflammatory Effects and the Therapy to Acute Lung Injury of Emodin[J];Journal of Zhejiang Chinese Medical University;2013-10
2 WANG Fang-ling1,TIAN Feng-sheng2(1.Cangzhou Medical College,Cangzhou 061001,Hebei,China;2.Cangzhou Affiliated Integrated Traditional Chinese and Western Medicine Clinical Medical College of Hebei Medical University,Cangzhou 061001,Hebei,China);Research Progress of "Anti-inflammatory" about Sanhuang Tablet and the Components[J];Journal of Liaoning University of Traditional Chinese Medicine;2011-09
3 CHEN Guoling;REN Ran;ZHANG Yinghui;SONG Wei;KAO Xin;ZHANG Han;Department of Ophthalmology,the Second Hospital of Shandong University;Department of Radiology,the 5th People's Hospital of Jinan;Department of Medical Records,the Second Hospital of Shandong University;;Significance and effect of emodin on activation of nuclear factor-κB in corneas of keratitis rats[J];Journal of Shandong University(Health Sciences);2014-09
【Citations】
Chinese Journal Full-text Database 1 Hits
1 CHEN Guo-ling,WU Xin-yi(Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012,Shandong, China);Anti-inflammation effect of pyrrolidine dithiocarbamate on pseudomonas aeruginosa lipopolysaccharide induced keratitis in Wistar rats[J];Journal of Shandong Univenity(Health Scicnes);2005-08
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 CHEN Guo-ling1,2, CHEN Shuang3,LIU Yan-li1, WEI Lu-wan1,LIU Zhi-yu1 (1.Department of Anatomy,School of Medicine,Shandong University,Jinan 250012,China;2.Ophthalmic Center of Shandong University,Department of Ophthalmology,Second Hospital of Shandong University,Jinan 250033,China;3.People′s Hospital of Shanting District,Zaozhuang 277200,Shandong,China);Activation and significance of NF-κB induced by lipopolysaccharide in cultured human corneal fibroblasts[J];Journal of Shandong University(Health Sciences);2009-03
2 Li Zhizhe,Lu Jianhua,Zhang Wenfang.Department of Ophthalmology,Second Hospital of Lanzhou University,Lanzhou 730030,China;Influence of nuclear factor-κB inhibitor on cataract formation after alkali burn[J];Chinese Ophthalmic Research;2009-11
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Tu Zeng hong, Shen Chun yi, Wang Mei ying, Qi Xiao dong Shanghai Institute of Materia Medica, Chinese Academy of Acicncc, Shanghai, 200031;THE MUTAGENICITY OF DRUGS AND THEIR EFFECT ON DNA CIRCULAR DICHROISM SPECTRA[J];Carcinogenesis,Teratogenesis and Mutagenesis;1993-02
2 XIA Lun-zhu,XU Xian-xiang,ZHANG Rui(The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine,Anhui,Hefei 230031);Effect of total saponins of clematis on adjuvant arthritis in rats[J];Anhui Medical and Pharmaceutical Journal;2009-04
3 WANG Xin hua, ZHEN Yong su*Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P.R.China;Inhibitory Effect of Emodin on Metastasis Associated Properties of PG Cells from a Human highly Metastatic Giant Lung Carcinoma Cell Line[J];Chinese Journal of Cancer;2001-08
4 Zhu Feng△, Liu Xin Guang, Liang Nian Ci Institute of Biochemistry and Molecular Biology,Guangdong Medical College,Zhanjiang, Guangdong,524023,P.R.China;Effect of Emodin and Apigenin on Invasion of Human Ovarian Carcinoma HO-8910PM Cells In Vitro[J];Chinese Journal of Cancer;2003-04
5 Liu Jian-Bo1, Gao Xue-Gang1, Lian Tao1, Zhao Ai-Zhi2, Li Kai-Zong2 1.Department of Surgery,Jingyang Hospital, Jingyang,Shaanxi,713700, P.R.China 2.Department of Hepatobiliary Surgery,Xijing Hospital,The Fourth Military Medical University, Xian,Shaanxi,710032, P.R.China;Apoptosis of Human Hepatoma HepG2 Cells Induced by Emodin In Vitro[J];Chinese Journal of Cancer;2003-12
6 LIU Mu-lin,LIU Rui-lin,JIANG Cong-qiao,MA Liang-long,FANG Xian-ye (Department of Gastrointestinal Surgery,Affiliated Hospital of Bengbu Medical College,Bengbu 233004,China);Influence of emodin on pancreatitic acinar cell apoptosis in rats with acute pancreatitis[J];Journal of Bengbu Medical College;2005-02
7 WU Wei,ZHANG Jia,LIU Mu-lin,CHENG Xing-wang(Department of Gastrointestinal Surgery,Affiliated Hospital of Bengbu Medical College,Bengbu 233004,China);Role of emodin and somatostatin in protection of intestinal mucosal barrier cells in rats with acute pancreatitis[J];Journal of Bengbu Medical College;2006-02
8 Meng Yun 1,2 Yan Bao zhen 1* Hu Gao fei 1 Lü Yü guang 1,2 Liu Yang 2(1 College of Science, Beijing University of Chemical Technology, Beijing 100029; 2 State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Center for Molecular Science, Institute of Chemistry, the Chinese Academy of Sciences, Beijing 100080, China);Determination of components of anthraquinones in Aloe vera[J];Journal of Beijing University of Chemical Technology;2004-03
9 WANG TianQi LI HanXiang YAO JinXiao TAN TianWei(College of Life Science and Technology,Beijing University of Chemical Technology,Beijing 100029,China);Synthesis of quaternary ammonium-glucan and its qantibacterial activity[J];Journal of Beijing University of Chemical Technology(Natural Science Edition);2007-04
10 LIU Ying, LI Jing-lu, YANG Sheng-hui, XIE Mei-hui, HUANG Li-hua. Faculty of Stomatology ,Capital University of Medical Sciences,Beijing 100050;The experimental study of anti-bacteria function of RCC[J];Beijing Journal of Stomatology;2005-02
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 CHEN Guoling;REN Ran;ZHANG Yinghui;SONG Wei;KAO Xin;ZHANG Han;Department of Ophthalmology,the Second Hospital of Shandong University;Department of Radiology,the 5th People's Hospital of Jinan;Department of Medical Records,the Second Hospital of Shandong University;;Significance and effect of emodin on activation of nuclear factor-κB in corneas of keratitis rats[J];Journal of Shandong University(Health Sciences);2014-09
2 XIANG Hui,PAN Xiao-li,XIE Yun-fei,ZHANG Cong-en,DONG Xiao-ping *(Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China);Concentration for 50% of Maximum Effect Study of Antioxidant Activity of 3 Emodin Metal Complex[J];Chinese Journal of Experimental Traditional Medical Formulae;2013-14
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