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《Journal of Shandong University(Health Sciences)》 2011-02
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Clinical effectiveness of dendritic cells therapy combined with intravesical perfusion of epirubicin on bladder cancer after TURBT

NI Yong-liang,LI Qing(Department of Urology,Qianfoshan Hospital of Shandong University,Jinan 250014,China)  
Objective:To evaluate the effectiveness of intra-dermal injection of dendritic cells combined with intra-vesical perfusion of epirubicin(EPI) on preventing recurrence of bladder cancer after TURBT.Methods:106 bladder cancer patients were randomly divided into two groups after TURBT,group A was treated with intradermal injection of dendritic cells combined with intravesical perfusion of EPI,while group B was treated only with intra-vesical perfusion of EPI.All patients were followed up for at least 2 years.T-lymphocyte subsets,tumor recurrence rates and adverse reactions of patients were observed and compared.Results:CD3+,CD4+ and CD4+/CD8+ of group A increased after dendritic cells therapy.Compared with that before the therapy and that of group B,the differences were significant(P0.05).2-year recurrence rates of group A and group B were 10% and 25.8%,respectively.The difference was significant(P0.05).3 patients of group A developed modent dermal inflammation after dendritic cells therapy.Conclusions:Compared with simple intra-vesical perfusion of EPI,DC therapy combined with intravesical perfusion of EPI can effectively reduce 2-year recurrence rate of bladder cancer after TURBT.Therefore,DC immune therapy combined with intra-vesical chemotherapy provides a new way for the adjuvant treatment of bladder cancer.
【CateGory Index】: R737.14
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 Yan Dong1,Ding Guofu1,Ni Zhao1,Li Yinglong1,Wang Xinmin1,Xie Shunmimg1,Wang Jiangping1,Wang Qinzhang2(1.Medical College of Shihezi University;2.Department of Urology,the First Affiliated Hospital of Medical College,Shihezi University,Shihezi 832008,China);The change of immunology function of dendritic cells from bladder carcinoma patients[J];Journal of Modern Urology;2008-05
2 JIAO Qing-fang, SONG Fang-zhou, YI Fa-ping (Department of Immunology, Chongqing Medical University, Chongqing 400016, China);Advance in Dendritic Cell Vaccine and Cellular Immune Therapy of Cervical Cancer[J];Chinese Journal of Biologicals;2010-04
3 CAO Zhi-xin,CHENG Xiao-ping,WU Zai-de(Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology ,Wuhan 430030,China);Study on T lymphocyte subsets immunological condition of spleen in hepatocellular carcinoma with liver cirrhosis[J];Chinese Journal of General Surgery;2002-06
【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 GAO Yong,HUANG Chen,TAN Yi,LIU Jin-xin,LI Zong-kuang,LIU Hui-chun,CUI Pei-yuan(Department of General Surgery,Affiliated Hospital of Bengbu Medical College,Bengbu 233004,China);Changes of spleen function of hepatic cirrhosis after liver transplantation in rats[J];Journal of Bengbu Medical College;2007-02
2 Wang Gongping,Feng Xiaoshan,Zhou Bo.Institution of Oncology,Department of Oncology,The First Affiliated Hospital,Henan University of Science and Technology,Henan 471003,China;The Relationship between the Amount of CD3~+ T Cells and the Clinical Pathological Index in Gastric Cardia Carcinoma[J];Journal of Medical Research;2009-05
3 JIANG Jing.Department of Gastroenterology,The Second Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116027,China;Clinical investigation on the immune state of patients with hepatic cirrhosis and primary hepatic carcinoma[J];Chinese Journal of Primary Medicine and Pharmacy;2006-12
4 TAN Yi,HUANG Chen,LI Zong-kuang,GAO Yong,CUI Pei-yuan,LIU Hui-chun,LIU Jin-xin.Department of General Surgery,Affilicated Hospital,Bengbu Medical College,Bengbu 233004,China;Effects of Liver Transplantation on Splenic Function in Rats with Hepatic Cirrhosis[J];Chinese Journal of Bases and Clinics in General Surgery;2006-02
5 CHEN Xiang ping 1 ,TANG Zheng hua 1,ZHANG Yu hua 1 ,YU Mei ying 2(1.Department of General Surgery, Xiangxiang City People′s Hospital,Xiangxiang,Hunan 411400,China; 2.Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China );Hepatectomy for hepatocellular carcinoma associated with cirrhosis[J];Chinese Journal of General Surgery;2005-02
6 LIU Jang-Hui,LI Jian-Tao,HE Yu-Tong,et al.Department of Hebei Provincial Tumor Institute,the Fourth Affiliated Hospital,Hebei Medical University,Shijiazhuang 050011,Hebei,China;Detecting of T lymph cells and NK cells of esophageal carcinoma and cardia carcinoma patients and their significance[J];Chinese Journal of Gerontology;2010-06
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 Wang Xiangwei, Yang Tangjun, Wang Zehou, He Bin, Jin Huansheng, Zen Yi, Liu Suying (Department of Urology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037);Induction of apoptosis by adriamycin in multidrug resistant human bladder cancer cell lines[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;1998-02
2 Yong-Jun Deng,1,2 Lan-Jun Zhang,1,2 Xiao-Dong Su,1,2 Dong-Kun Zhang,1,2 Tie-Hua Rong,1,2 Qi-Jing Wang1 and Jian-Chuan Xia1 1.State Key Laboratory of Oncology in South China,Guangzhou,Guangdong,510060,P.R.China 2.Department of Thoracic Surgery,Sun Yat-sen University Cancer Center,Guangzhou,Guangdong,510060,P.R.China;Dendritic cell-tumor cell fusion vaccine prevents growth of subcutaneous transplanted esophageal carcinomas[J];Chinese Journal of Cancer;2009-10
3 CAO Zhixin,CHEN Xiaoping,WU Zaide.Hepatic Surgery Center,Ton gji Hospital,Tongji Medical College,Huazhong University of Science and Technol ogy,Wuhan 430030,China;A study on the spleen Th1/Th2 cytokines immunological condition in the patients with primary hepatocellular carcinoma combined with liver cirrhosis[J];Chinese Journal of Experimental Surgery;2001-06
4 CAO Zhixin, CHEN Xiaoping, WU Zaide Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430030, China;Changes of immune function in liver cirrhosis patients after splenectomy combined with resection of hepatocellular carcinoma[J];Chiese Journal of Surgery;2002-02
5 ZHANG Yi *, CHEN Pan, ZHANG Yanyun, et al. * Immunology Research Unit, Suzhou Medical College, P.R. China; No. People′s Hospital of Suzhou, P.R. China; Department of Molecular Preventive Medicine, School of Medicine, The University of Tokyo, Japan;Transforming growth factor β1 inhibits the generation of dendritic cells from murine hematopoietic progenitor cells in vitro[J];NATIONAL MEDICAL JOURNAL OF CHINA;1999-03
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