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《Journal of Shandong University(Health Sciences)》 2011-02
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Clinical effectiveness of dendritic cells therapy combined with intravesical perfusion of epirubicin on bladder cancer after TURBT

NI Yong-liang,LI Qing(Department of Urology,Qianfoshan Hospital of Shandong University,Jinan 250014,China)  
Objective:To evaluate the effectiveness of intra-dermal injection of dendritic cells combined with intra-vesical perfusion of epirubicin(EPI) on preventing recurrence of bladder cancer after TURBT.Methods:106 bladder cancer patients were randomly divided into two groups after TURBT,group A was treated with intradermal injection of dendritic cells combined with intravesical perfusion of EPI,while group B was treated only with intra-vesical perfusion of EPI.All patients were followed up for at least 2 years.T-lymphocyte subsets,tumor recurrence rates and adverse reactions of patients were observed and compared.Results:CD3+,CD4+ and CD4+/CD8+ of group A increased after dendritic cells therapy.Compared with that before the therapy and that of group B,the differences were significant(P0.05).2-year recurrence rates of group A and group B were 10% and 25.8%,respectively.The difference was significant(P0.05).3 patients of group A developed modent dermal inflammation after dendritic cells therapy.Conclusions:Compared with simple intra-vesical perfusion of EPI,DC therapy combined with intravesical perfusion of EPI can effectively reduce 2-year recurrence rate of bladder cancer after TURBT.Therefore,DC immune therapy combined with intra-vesical chemotherapy provides a new way for the adjuvant treatment of bladder cancer.
【CateGory Index】: R737.14
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