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《Journal of Shandong University(Health Sciences)》 2013-05
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Effects of Piper Kadsura Ohwi extracts on β-amyloid protein-induced activation of microglia in vitro

HAN Xiao-juan1,MA Xue-qiang2,DU Yi-feng1(1.Department of Neurology,Provincial Hospital Affiliated to Shandong University,Jinan 250021,China; 2.The First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,Zhejiang,China)  
Objective To explore the effects of oligomeric forms of β-amyloid protein(Aβo) on microglia and to analyze the influence of Piper Kadsura Ohwi extracts on this progress.Methods Microglia taken from newborn Wistar rats(within 3days) was cultured,purified and identified.Piper Kadsura Ohwi was extracted by using ethanol.Such an extract was blended with DMSO in the proportion of 4∶ 1 followed by being filtered and concentrated,then normal saline solution(NS) was added and the mix was filtrated by microporous filtering film.Microglia inoculated into 96-well plates was divided into 4 groups: blank group,Aβo group,Aβo+KPSE group and Aβo+DMSO group,and cultured for 48 hours.TNF-α and TGF-β1 levels in cell supernatant liquid were detected by enzyme-linked immunosorbent assay(ELISA).Results The expression of TNF-α and TGF-β1 was increased by the stimulation of Aβo compared with the blank group.The expression of inflammatory factors in KPSE group was lower than the control group.Conclusion Micoglia could be activated and the level of inflammatory factors could be increased by Aβo,and these incidents could be suppressed by KPSE.
【Fund】: 国家自然科学基金(30973816);; 山东省科技发展计划项目(2010GSF10229)
【CateGory Index】: R285.5
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