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《Journal of Capital Medical University》 2007-03
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Effects of Endotoxemia on Oxidative Stress and NO Levels of Streptozocin-induced Diabetic Rats

Yang Zhihong,Zhong Liyong,Wang Hui(Department of Endocrinology,Beijing Tiantan Hospital,Capital Medical University)  
Objective To investigate the effects of endotoxemia on parameters of oxidative stress and NO levels of streptozocin-induced diabetic rats.Methods Experimental diabetic animal models were constructed by streptozocin injection(50 mg/kg,i.p).The endotoxemia condition was then induced by LPS(0.5 mg/kg,i.p.).Parameters related to oxidative stress such as SOD,MDA,GSH,NO and concentrations of glucose and insulin were measured at 6,12,24 and 72 h after injection of LPS.Results The levels of serum NO and MDA elevated significantly at 24 h after LPS injection(P0.05),whereas the levels of SOD and GSH decreased significantly at 24 h after LPS injection(P0.05).Though no significant difference was seen in blood glucose levels in these DM groups before LPS injection,they elevated at 12,24 and 72 h after LPS injection.The insulin levels decreased in diabetic rats significantly at 24 and 72 h after LPS injection.Conclusion Endotoxemia would reduce the antioxygenic ability in diabetic rats,elevate the production of NO and impair the regulatory ability to blood glucose.
【CateGory Index】: R587.1
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