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《Journal of Capital Medical University》 2008-05
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Susceptibility Surveillance of Gram-positive Bacteria to Antibiotics Among Children in China:A Study in Beijing,Shanghai,Guangzhou and Chongqing during the Period of 2000-2006

Wang Ling1,Shen Xuzhuang1,Lu Quan2,Wang Yi5,Zeng Qiyi3,Chen Yuan4,Wan Chuanqing5,Deng Qiulian3,Liu Lan4,Zhen Jinghui1,Zhang Hong2,Yang Yonghong1(1.Beijing Children's Hospital,Capital Medical University;2.Shanghai Children's Hospital,Affiliated to Jiaotong University;3.Guangzhou Children's Hospital;4.Children's Hospital of Chongqing Medical University;5.Children's Hospital of Fudan University)  
Objective To obtain a better insight of the drug-resistance rate of gram-positive cocci isolated from patients of 5 pediatric hospitals located in different areas of China.Methods From Jan 1st 2000 to Dec 31st 2006,a total of four type pathogenic strains were isolated from 5 pediatric hospitals which are Beijing Children's Hospital,Children's Hospital of Fudan University,Shanghai Children's Hospital,Guangzhou Children's Hospital and Chongqing Children's Hospital with both hospital acquired infection(HAI)and community acquired infection(CAI),and the number of the strains is 8 215.The all 12 063 strains were tested using Kirby-Bauer method.According to the criteria of guidelines of NCCLS of each year from 2000 to 2006,the R% were calculated to show the resistance and intermediate,and the S% for susceptible rate of bacteria to the compound tested.We chose Penicillin,Oxacillin,Amoxicillin and Clavulanat,Clindamycin,Cefuroxime,Ceftriaxone,Erythromycin,Compound Sulfamethoxazole and Vancomycin for testing S.aureus;Penicillin,Erythromycin,Clindamycin,Vancomycin,Ofloxacin and Compound Sulfamethoxazole for testing S.pneumoniae;Penicillin,Erythromycin,Clindamycin,Vancomycin and Ofloxacin for testing Group A streptococci;Ampicillin,Streptomycin(highconcentration),Gentamycin(high concentration,Ciprofloxacin,Vancomycin,Teicoplanin,Erythromycin and Rifampicin for testing Enterococcus.Results Among a total of 4 781 strains of S.aureus,the detectable rates of methicilin-resistant Staphylococcus aureus(MRSA)were6.87%,and the rate of resistance to erythromycin was 66.39% while the rate was rising.The rate of MRSA from two hospitals in Shanghai were higher than the others.All S.aureus isolates were susceptible to vancomycin;4 781 strains of S.pneumoniae were isolated.The rate of penicillin unsusceptible Streptococcus pneumoniae(PRSP)was 68.64%,and the rate of resistance to erythromycin was 90.80% while the rate of both were going up;The total strains of 1 301 Group A streptococci were all susceptible to penicillin,with the rate of resistance to erythromycin was 80.94% which was rising by year,and we can see that rate of erythromycin-resistant were various from 100% to 52.08% by area;3.11% of all 1377 isolated Enterococcus strains were found intermediate to vancomycin,and the rate of ampicillin resistance was 48.03%.The rate of resistance to erythromycin was 86.47%.Conclusion Except Group A streptococci,G+ coccus have a high resistance rate to penicillin;almost all G+ coccus were susceptible to vancomycin and teicomycin,but resistant to erythromycin with a trend of rising.MRSA was low in rate,and we haven't find VRSA and VISA.But there was 3.11% of Enterococcus intermediate to vancomycin.So we should pay more attention to it.Antimicrobial resistant coccus of pediatric has already become a serious problem in China.Ongoing surveillance study on the antimicrobial resistance of gram-positive coccus is necessary for appropriate antimicrobial use in pediatric clinical work.
【Fund】: 国家“十五”科技攻关课题(2004BA720A09-01)资助项目~~
【CateGory Index】: R446.5
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Chinese Journal Full-text Database 2 Hits
1 LI Chang-chong,LIN Li(Department of Pulmonology,Yuying Children's Hospital Affiliated to Wenzhou Medical College,Wenzhou 325027,Zhejiang,China);Common bacteria for lower respiratory tract infection in children and its current status of antibiotic resistance[J];Journal of Clinical Pediatrics;2010-02
2 WANG Qun 1,YANG Yong-hong 2,GENG Wen-jing 2,WU De-jing 2,YUAN Lin 2,YU Sang-jie 2,SHEN Xu-zhuang 2 (1.Department of Pediatrics,the Affiliated Hospital of Guilin Medical College,Guilin 541001,Guangxi Zhuang Autonomous Region,China;2.Laboratory of Microbiology and Immunology,Beijing Children′s Hospital Affiliated to Capital Medical University,Beijing 100045,China);Clinical Characteristics and Antibiotic Resistance of Staphylococcus Aureus from Skin and Soft Tissue Infections in Children[J];Journal of Applied Clinical Pediatrics;2009-22
Chinese Journal Full-text Database 7 Hits
1 GUO Yufen, ZHEN Jinghui, ZHANG Meihe, et al.Department of Clinical Laboratory, Beijing Children's Hospital, Capital University of Medical Sciences, Beijing 100045, China;Changes of bacteria detected from blood culture of pediatric patients in 17 years and analyses of antimicrobial resistance[J];Chinexe Journal of Pediatrics;2000-12
2 DONG Taiming *, SU Jian, HUANG Zhendong, et al. * Rheumatic Fever Laboratory Guangdong Provincial Cardio Vascular Disease Institute, Guangzhou 510100;An antibiotic resistance epidemiologic study of group A streptococci isolated from elementary school children in 4 provinces of China[J];Chinexe Journal of Pediatrics;1999-01
3 LI Jia-tai, LI Yun, WANG Jin, on behalf of China Bacterial Resistance Surveillance Study Group. Department of Antibiotics, Institute of Clinical Pharmacology, Peking University, Beijing 100083, China;Surveillance on gram-positive bacteria isolated from patients with hospital acquired infections or community acquired infections[J];National Medical Journal of China;2003-05
4 LIU Gui-jian, XU Shu-zhen, MA Yue, LI Jing-yun. Laboratory Department of Microbiology, Beijing Friendship Hospital, Capital University of Medical Science, Beijing 100050, China;Analysis of antimicrobial resistance of clinical isolates of enterococci from Beijing and other areas in China[J];National Medical Journal of China;2003-12
5 YAO Kai-hu~*, LU Quan, DENG Li, YU Sang-jie, ZHANG Hong, DENG Qiu-lian, SHEN Xu-zhuang, YANG Yong-hong. ~*Beijing Children′s Hospital, Capital University of Medical Sciences, Beijing 100045, China;Carrier rate of Streptococcus pneumoniae and susceptibility thereof to antimicrobial drugs among children in China: a surveillance study in Beijing, Shanghai, and Guangzhou 2000—2002[J];National Medical Journal of China;2005-28
6 HU Hong bing, LIU Ling, LUO De juan, YANG Lao rong (Department of Laboratory Medicine, Children Hospital of Wuhan, Wuhan 430060, China);Nosocomial Infection and Drug Resistance of Staphylococcus Spp. from Clinical Isolates in Children Hospital[J];Chinese Journal of Nosoconmiology;2005-02
7 WANG Qian, CHU Yun-zhuo, DENG Yu-xin(Department of Laboratory, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R.China);Streptococcus beta-haem clinical distribution surveillance and resistance analysis in five years[J];China Journal of Modern Medicine;2004-20
Chinese Journal Full-text Database 10 Hits
1 CH EN Ke ZHU jun DING Xiao-mei Department of Cardiology,AnHui pro vinceial Hospital ,Hefei 230001;The clcnical analysis on 30 patients with infective endocarditis[J];Journal of Anhui Health Vocational & Technical College;2003-05
2 ZHANG Mao-yan, TANG Zhong-yingAnhui Provincial Children's Hospital ,Hefei 230051,China;Analysis of 49 cases of sepsis in children[J];Journal of Anhui Health Vocational & Technical College;2005-01
3 QIN Ke-xiou,YE Li-jun,WANG Zhong-xin(Department of Infection,The First Affiliated Hospital,Anhui Medical University,Hefei,Anhui 230022);Distribution and antibiotic susceptibility change of pathogenic of 747 stains in blood culture[J];Anhui Medical and Pharmaceutical Journal;2008-03
4 LIU Pengpeng, ZHANG Shaoyan, LI Hui, et al\ Clinical Laboratory, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003\;;A DETECTION OF MRCNS IN NEONATAL SEPTICEMIA[J];Acta Acadimae Medicinae Qingdao;2001-04
5 GAO Wei,YAO Kai-hu,YU Sang-jie,et al(Beijing Children's Hospital,Beijing 100045);Antibiotic resistance of serogroup 19 streptococcus pneumoniae isolated from children in Beijing Children's Hospital from 2000 to 2005[J];Beijing Medical Journal;2009-01
6 FAN Shao-zhen,WANG Ai-hua(Beijing Children's Hospital,Beijing 100045);Analysis of nosocomial infections in pediatric haematology ward from 1997 to 2006[J];Beijing Medical Journal;2009-07
7 HUANG Yong,WAN Gen-Ping,ZHOU Zhen-Wen,DENG Qiu-Lian,HUANG Xu-Qiang,DENG Li,ZHAO Chang-An.Department of Clinical Laboratory,Guangzhou Children's Hospital,Guangzhou 510120,China;Antimicrobial resistance and penicillin resistance-associated genes of Streptococcus pneumoniae isolated from children with respiratory tract infection[J];Chinese Journal of Contemporary Pediatrics;2009-08
8 ;耐甲氧西林葡萄球菌的分布及耐药性分析[J];Contemporary Medicine;2009-15
9 XIE Yong-qiang,CHEN Zhao-hong,DENG Qiu-lian,WAN Gen-ping.(Guangzhou Children's Hospital,Guangzhou,Guangdong 510120,China);Analysis of drug-resistance and emm gene genotype of group A streptococcus in children[J];Chinese Journal of Child Health Care;2008-04
10 Jian-Dang Zhou, Jian-Jun Guo, Qin Zhang, Yin Chen, Shai-Hong Zhu and Huai-Yan Peng Department of Clinical Laboratory Institute of Organ Transplantation the Third Xiangya Hospital of Central South University; Department of Medical Laboratories College of Medical Technology and Information of Central South University, Changsha 410013, China;Drug resistance of infectious pathogens after liver transplantation[J];国际肝胆胰疾病杂志(英文版);2006-02
China Proceedings of conference Full-text Database 1 Hits
1 DU Na, WANG Hui, NIU Jun-qi, SUN Hong-li, CHEN Min-jun, HU Bi-jie, YU Yun-song, SUN Zi-yong, CHU Yun-zhuo. Department of Infectious Diseases, The First Affiliated Hospital of the Bethune Medical College, Jilin University;The detection of SCCmec typing and toxic genes of methicillin-resistant staphylococcus aureus at five teaching hospitals in China.[A];[C];2006
Chinese Journal Full-text Database 10 Hits
1 DENG Qiu-lian1,DENG Li1,XIE Yong-qiang1,HUANG Yong1,ZHONG Hua-min1,YANG Yong-hong2(1.Guangzhou Children's Hospital,Guangzhou 510120,China;2.Beijing Children's Hospital,Beijing 100000,China);Analysis on drug-resistance of Staphylococcus aureus causing infection in children[J];Chinese Journal of Infection Control;2008-01
2 ZHUO Chao, SU Dan-hong, ZHU De-mei, HU Fu-pin, WANG Fu, RUAN Fei-yi, SUN Zi-yong, JIAN Cui, XU Ying-chun, SUN Hong-Li, NI Yu-xing, SUN Jing-yong, YU Yun-song, YANG Qing, WANG Chuan-qing, XUE Jian-chang, ZHANG Hong, LI Wan-hua, HU Yun-jian, AI Xiao-man, JIA Bei, HUANG Wen-xiang, WEI Lian-hua, WU Ling, ZHANG Zhao-xia, JI Ping. (State Key Laboratory of Respiratory Diseases, Guangzhou 510120, China);CHINET 2007 surveillance of antimicrobial resistance in E. coli and Klebsiella spp.[J];Chinese Journal of Infection and Chemotherapy;2009-03
3 ZHANG Hong, LI Wan-hua, WANG Chuan-qing, XUE Jian-chang, SUN Zi-yong, JIAN Cui, HU Yun-jian, AI Xiao-man, XU Ying-chun, SUN Hong-li, WEI Lian-hua, WU Ling, ZHUO Chao, SU Dan-hong, YU Yun-song, YANG Qing, HU Fu-pin, ZHU De-mei. (Child-ren′s Hospital, Shanghai Jaotong University, Shanghai 20040, China);CHINET 2007 surveillance of antimicrobial resistance in Haemophilus influenzae in China[J];Chinese Journal of Infection and Chemotherapy;2009-03
4 XU Min,ZHANG Jian-hua,WU Liang-xia,WANG Zi-cai (Department of Pediatrics,the Sixth People′s Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200233,China);Drug Sensitive Analysis of 207 Strains of Staphylococcus Aureus in Children[J];Journal of Applied Clinical Pediatrics;2008-10
5 WANG Ling ,LU Quan, WANG Chuan-qing , DENG Qiu-lian, LIU Lan, ZHEN Jing-hui, ZHANG Hong, WANG Yi , HUANG Yong, CHEN Yuan, YANG Yong-hong, SHEN Xu-zhuang (Children's Hospital of Capital University of Medical Sciences, BeijingA 100045;Children's Hospital of Jiaotong University, Shanghai 200040;Children 's Hospital of Fudan University, Shanghai 200032;Guangzhou Children's Hospital, Guangzhou 510120; Children's Hospital Affiliated to Chongqing University, Chongqing 400014);Susceptibility of Gram-positive bacteria to antimicrobial drugs among pediatric patients in China: an analysis of hospital data from Beijing, Shanghai, Guangzhou and Chongqing 2000-2004[J];Chinese Journal of Evidence-Based Pediatrics;2006-02
6 Li Shan,Hua Chunzhen,Xu Liqun.Department of Pediatrics,Hangzhou No.2 People's Hospital,Hospital Affiliated to Hangzhou Normal University;Zhejiang 310015,China;Study on Drug-resistance of Staphylococcus Aureus Isolated from Children in Hangzhou[J];Journal of Medical Research;2007-12
7 GAO Wei, BAI Xiang jun ( Department of Traumatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China );The Bacteriology and Drug Sensitivity Analyses of 50 Outpatients with Skin and Soft Tissue Infection[J];Herald of Medicine;2002-04
8 WANG Hui~* SUN Hong-li CHEN Min-jun LIU Yong YU Yun-song HU Yun-jian HU Bi-jie NI Yu-xing XI Yun SUN Zi-yong SHEN Ding-xia XU Ying-chun XIE Xiu-li ~* Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China;Resistance surveillance of common community respiratory pathogens isolated from 9 teaching hospitals in China,2005-2006[J];Chinese Journal of Laboratory Medicine;2007-11
9 Jian Cui,Ye Tao,Zhang Bei,Li Li,Wang Bin,Chen Zhong-ju,Tian Lei and Sun Zi-yong(Tongji Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030);2006~2007 Mohnarin report:Bacterial distribution and resistance in central-southern China[J];Chinese Journal of Antibiotics;2008-10
10 DAI Chun-juan,YE Zu-ping,HU Bo,et al.Department of Pediatric Surgery,Tianjin Children's Hospital,Tianjin 300074,China;Analysis of susceptibility of staphylococcus aureus in neonatal soft tissue infection[J];China Practical Medicine;2008-10
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Yuan Lin, et al(Laboratory of Microbiology and Immunology Beijing Children's Hospital, Beijing 100045);A study of antibiotic sensivity tests on Group A streptocci[J];BEIJING MEDICAL JOURNAL;1995-03
2 MA Yue, YAO Lei, CHEN Hongbo, et al. National Institute for the Control of Pharmaceutical and Biological Products, National Center for Surveillance of Antimicrobial Resistance, Beijing 100050,China;A study on antimicrobial resistance of clinical isolates of Staphylococcus species[J];Chinese Journal of Infection and Chemotherapy;2002-01
3 ZENG Xuefeng, LEI Binjun, LU Xiaoju, FAN Xinjian, FENG Ping, YU Rujia. (The Center of Infectious Disease, West China Hospital, Sichuan University, Chengdu 610041, China);Antimicrobial resistance of Streptococcus pneumoniae and mechanisms of resis-tance to macrolides[J];Chinese Journal of Infection and Chemotherapy;2004-03
4 WEI Guoyi,FAN Maohuai,YANG Yonghong,CUI Zheng(Beijing Children’s Hospital Affiliated to Capital University of Medical Sciences,Beijing100045);Analysis of Antibiotics Used in Beijing Children’s Hospital in the Years1996~2001[J];China Pharmacy;2003-04
5 Wang Fu;Zhu Demei;Zhang Yingyuan.(Iiistitute of Antibiotics,Hua Shan Hospital,Shanghai Medical Uni-versyty,Shanghai 200040);Bacterial resistance of clinical isolates in Shanghai hospital and its clinical implications[J];CHINESE JOURNAL OF INFECTIOUS DISEASES;1996-03
6 LI Xiangyang, YANG Jinhong, LI Fangqu, TAO Hongqun. The 2nd Affiliated Hospital of Wenzhou Medical College,Wenzhou 325027,China;The state of infection and resistance of Methicillin-resistant Staphylococcus in pediatrics[J];Chinexe Journal of Pediatrics;2002-05
7 HUA Chun zhen, SHANG Shi qiang, SUN Xiao feng, LI Jian ping, CHEN Zhi min, YU Xi lin. Department of Central Laboratory, Children′s Hospital Affiliated to Medical College, Zhejiang University, Hangzhou 310003, China;Antibiotics-resistance pattern and genetic type of Streptococcus pneumoniae isolated from children in Hangzhou[J];Chinese Journal of Pediatrics;2004-01
8 LI Jie, YANG Yonghong, YU Sangjie, et al Beijing Childrens Hospital Affiliated to Capital University of Medical Sciences, Beijing 100045;Antimicrobial resistance of Streptococcus pneumoniae: a comparison between the middle of 1980s and 1990s[J];Chinexe Journal of Pediatrics;1999-07
9 LEI Yanchang, GUI Xien, FENG Guoqin.The Second Affiliated Hospital, Hubei Medical University, Wuhan 430071, China;A study on the resistance of Staphylococcus aureus and the mechanisms of its resistance to fluoroquinolone[J];Chinese Journal of Internal Medicine;2001-03
10 WANG Hui, CHEN Minjun Department of Laboratorg Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100730,China;Resistance mechanism of erythromycin in Streptococcus pneumoniae[J];Chinese Journal of Laboratory Medicine;2002-03
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