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《Journal of Pharmaceutical Research》 2013-03
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Research on hypolipidemic effect of synbiotics in Hyperlipidemia rats

CHENG Xiu-fang,LIU Hong,WANG Cong-cong,LI Dan,XIE Li-min,GU Wei(Shandong Boly-lely Biongineering Co.,Ltd.,Taian 271000,China)  
Objective To investigate the hypolipidemic effect of synbiotics composed of two strains of probiotics(Streptococcus thermophilus,Lactobacillus plantarum)and two kinds of prebiotics in Hyperlipidemia rats.Methods Build lipid metabolism disorder model using Wistar rats,set up three dose groups respectively 2.25,0.45,0.09 g·kg-1,a model group and a normal group,Gavage 30 days,Detect the level of total cholesterol(TC),triglyceride(TG)and high-density lipoprotein cholesterol(HDL-C)of rat serum using Biochemical kit,and detect the liver spleen and kidney index.Results Synbiotics had no effects on feed intake and liver spleen kidney index.Three synbiotics dose groups(treatment group)could significantly reduce the levels of total cholesterol(TC)and triglyceride(TG)compared with the control group.TC and TG of rats in the model group compared with normal groups were significantly increased(P0.01),showed that the model was established,three synbiotics dose group(treatment group)of TC and TG than that in the model group significantly decreased(P0.01).Conclusion Synbiotics had good function of reducing blood lipid.
【CateGory Index】: R96
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