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《Journal of Pharmaceutical Research》 2018-10
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The immune intervention effect of crude polysaccharide from Ranunculus ternatus Thunb.on experimental autoimmune thyroiditis (EAT) mice

FENG Yiping;GUO Liwen;PAN Huiwen;Guangxi University of Science and Technology;  
Objective To study the immune intervention effect of crude polysaccharide from Ranunculus ternatus Thunb.on experimental autoimmune thyroiditis( EAT) mice.Methods Female BALB/c mice were given multipoint injections of thyroglobulin with adjuvants subcutaneously and fed by water with high iodine level. When the EAT model was formed,drugs were used for treatment.The levels of serum thyroxine( TT4),triiodothyronine( TT3),free thyroxine( FT4),free triiodothyronine( FT3) and highly sensitive human thyrotropin( TSH) in EAT mice were detected by chemiluminescence,and the levels of anti-thyroglobulin antibody( TGAb) and anti-thyroid microsome were detected by radioimmunoassay.Results Compared with the normal group,serum TT4,FT4 and FT3 of EAT were significantly decreased( P0.01),TSH,TGAb and TMAb were significantly increased( P 0.01),and TT3 was not significantly different from normal group.Compared with the model group,the levels of TT4,FT4 and FT3 in each dosage group were significantly increased( P 0.01),while the levels of TGAb and TMAb were still high.Conclusion The EAT mice are in a hypothyroidism state.The crude polysaccharide from Ranunculus ternatus Thunb. can interfere with the serum thyroid hormone levels in this type of EAT mice to a certain extent,which is beneficial to its recovery.The effect may be related to its anti-inflammatory and immunomodulatory functions.
【Fund】: 广西高校科学技术研究项目(No.KY2015LX191)
【CateGory Index】: R285.5
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