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《Journal of Pharmaceutical Research》 2018-10
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Differences of acute toxicity of four kinds of Radix Aconite

LI Pan;HAN Jia;ZHANG Shipeng;ZHANG Fan;School of Pharmacy,Institute of Materia Medica,North Sichuan Medical College;  
Objective To compare differences of acute toxicity and the consequent toxical performance on mice of four kinds of homologous herbal slices: Radix Aconite,Heifupian,Baifupian and Tianxiong. Methods Acute toxical tests were carried out on mice by gavage to get LD50 of extracts of Radix Aconite and Heifupian and get MTD of extracts of Tianxiong;while limit test was carried out on mice to observe toxical performance caused by extracts of Baifupian.Results The LD50 of Radix Aconite and Heifupian were 4.55 g·kg~(-1) and 78.71 g·kg~(-1),respectively,while the MTD of Tianxiong was 34.19 g·kg~(-1).Mice were dosed extracts of Baifupian in a dose of 5 g·kg~(-1),which caused severe toxical reactions but could not cause death. The toxical performance caused by above four slices were completely similar,which might be involved in nervous system,respiratory system and circulatory system.In addition,these slices except for Baifupian could cause exophthalmos,convulsions and even death.Conclusion The sequence of acute toxicity of above four slices was as follows: Radix Aconite,Heifupian,Tianxiong and Baifupian.Although the toxical performance they caused were extremely similar,they differed somewhat in severity.
【Fund】: 四川省教育厅重点项目(No.16ZA0232);; 化学生物学及中药分析教育部重点实验室资助(No.KLCBTCMR2015-02)
【CateGory Index】: R285.5
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