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《Journal of Shandong University of Traditional Chinese Medicine》 2009-04
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Protective effect of modified Dihuang Yinzi on the nerve cell in rats with focal cerebral ischemia

DUAN Xin-fen1,LI Wen-ying2,XIE Ning(21.College of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China;2.Heilongjiang University of Traditional Chinese Medicine,Haerbin 150040,China)  
Objective:To observe the protective effect and the mechanism of modified Dihuang Yinz(iMDY) on nerve cell in rats with focal cerebral ischemia.Methods:120 Wistar rats were divided into 6 groups randomly:normal group,model group,sham operated group,low dose of TCM group,high dose of TCM group and Acenterine group.Use the middle cerebral artery occlusion methods to make focal cerebral ischemia model rats after intragastric administra-tion for 7 days.To observe the activity of Na+-K+-ATPase,Ca2+-ATPase,SOD and the content of MDA in cerebral hippocampus.Results:To MCAO model rats,MDY could increase the activities of Na+-K+-ATPase,Ca2+-ATPase and SOD and decrease the content of MDA in cerebral hippocampus.Conclusion:MDY could protect the nerve cells in MCAO rats'brain,by the way of increasing activities of Na+-K+-AT-Pase,Ca2+-ATPase and SOD and decreasing the content of MDA.
【Fund】: 黑龙江省自然科学基金项目(编号:D0028)
【CateGory Index】: R285.5
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