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《Shandong Medical Journal》 2005-10
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Expression of IGF-Ⅱ and IGF-ⅠR in colorectal cancer

Guo Baowen,Wu Minlan,Yang Lin  
Objective To investigate the expression of Insulin-like growth foctor(IGF)-Ⅱ and IGF-ⅠR in colorectal cancer and their relationship with clinicopathological factors.Methods 40 fresh samples were obtained from patients who underwent colorectal cancer operation.For each patient,3 samples were obtained,which were respectively from the loci of cancer,1cm and 10cm from the loci of cancer.And 10 samples obtained from patients who underwent colorectal operation for non-neoplastic disease were used as control group.The expression of IGF-Ⅱ and IGF-ⅠR were studied by means of immunohistochemical assay(S-P method).Results The positive expression rate of IGF-Ⅱ and IGF-ⅠR in the loci of cancer group and paracancer group were higher than that of 10cm from the loci of cancer and control group(P0.05).There was no significant difference between the loci of cancer group and paracancer group 1cm from the loci of cancer(P0.05).There was no significant difference between the control group and the group 10cm from the loci of cancer(P0.05).There was a significant difference of the positive expression between the group of Dukes A,B and the group of Dukes C (P0.05),the same difference as between the group with lymph node metastasis and the group without lymph node melastasis,between the group with serosa ivasion and the group without serosa invasion.Conclusion The higher IGF-Ⅱ and IGF-ⅠR expression are correlated with the genesis,invasion and metastasis of colorectal cancer.
【CateGory Index】: R735.34
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