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《Shandong Medical Journal》 2005-10
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Effect of YSJZ decoction on mitochondrial functions induced by cerebral ischemia and reperfusion in mice

Qian Tao,Gao Weijuan,Cong Bin  
Objective To investigate the effects of YSJZ decoction on succinodehydrogenase (SDH),Cytochrome C oxidase (CCO) activities and velocity of mitochondrial ATP synthesis induced by cerebral ischemia and reperfusion in the hippocampus of hyperlipemia mice.Methods The model was established by repeated ischemia and reperfusion in hyperlipemia mice.The mitochondria were prepared by centrifugation,the activities of SDH and CCO were measured by biochemical methods and the velocity of mitochondrial ATP synthesis was determined by HPLC.Results The activities of SDH and CCO in hippocampus of model groups on 1,7,15 and 30d after operation were obviously lower than that of normal control groups (P0.01) and decreased continually with the prolongation of time.The velocity of mitochondrial ATP synthesis in hippocampus of model groups were significantly lower than that of normal control groups at every time point (P0.01).The activities of SDH and CCO in hippocampus and the mitochondrial ATP synthesis velocity of treatment groups at every time point after operation were higher than that of model groups(P0.05,0.01).Conclusion The YSJZ decoction exerts its protective effects to neuronal after cerebral ischemia and reperfusion via inhibiting the decrease of SDH and CCO activities,increasing the mitochondrial ATP synthesis velocity and improving the disorder of energy metabolism in hyperlipemia mice.
【Fund】: 承德市科技局科技攻关基金资助项目(No.20031016)
【CateGory Index】: R285.5
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