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《Shandong Medical Journal》 2005-18
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Evaluation of treatment with single dose Zenapsain muliple renal transplantation recipients

Lu Jinshan,Ao Jianhua,Gao Jiangping,et al  
Objective To investigate the clinical value of single dose anti IL-2R monoclonal antibody (Zenapax) therapy in multiple renal transplantation patients.Methods A total of 23 allograft recipients with multiple renal transplantation was randomized into observation group(n=11) and control group(n=12).The Immunosuppressive therapy were same after operation in two groups .Treated group received single dose(50mg) Zenapax intravenously before operation.Acute rejection(AR) episodes,delayed graft function,infection and related complications were analyzed in each group in 3 months post transplantation.T lymphocyte subsets CD3 and CD4 were sequentially monitored.Results The incidence of AR in observation group was much lower than that in control group.The rate of delayed graft function in two groups were similar,but the mean time of renal replacement in observation group was much shorter than in control group(P0.05).The incidence of allergy, cytokine release syndrome and infection in two groups had no significant diffrence.The CD3 and CD_4 subsets.decreased in both groups after operation but no significant difference between two groups((P0.05).)Conclusion The single dose of Zenapax can reduce the occurrence of AR obviously in multiple renal transplantation patients.It had no influence on T lymphocyte subsets and clinical infection rate
【CateGory Index】: R699.2
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