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《Shandong Medical Journal》 2005-18
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Evaluation of treatment with single dose Zenapsain muliple renal transplantation recipients

Lu Jinshan,Ao Jianhua,Gao Jiangping,et al  
Objective To investigate the clinical value of single dose anti IL-2R monoclonal antibody (Zenapax) therapy in multiple renal transplantation patients.Methods A total of 23 allograft recipients with multiple renal transplantation was randomized into observation group(n=11) and control group(n=12).The Immunosuppressive therapy were same after operation in two groups .Treated group received single dose(50mg) Zenapax intravenously before operation.Acute rejection(AR) episodes,delayed graft function,infection and related complications were analyzed in each group in 3 months post transplantation.T lymphocyte subsets CD3 and CD4 were sequentially monitored.Results The incidence of AR in observation group was much lower than that in control group.The rate of delayed graft function in two groups were similar,but the mean time of renal replacement in observation group was much shorter than in control group(P0.05).The incidence of allergy, cytokine release syndrome and infection in two groups had no significant diffrence.The CD3 and CD_4 subsets.decreased in both groups after operation but no significant difference between two groups((P0.05).)Conclusion The single dose of Zenapax can reduce the occurrence of AR obviously in multiple renal transplantation patients.It had no influence on T lymphocyte subsets and clinical infection rate
【CateGory Index】: R699.2
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Chinese Journal Full-text Database 1 Hits
1 Xing Li,Cai Wen-li,Miao Shu-zhai,Qu Qing-shan,Wang Pei-yu,Wang Kai Department of Organ Transplantation,the People's Hospital of Zhengzhou,Zhengzhou 450003,Henan Province,China;Pretreatment of interleukin-2 receptor monoclonal antibody combined with immunoadsorption in 24 sensitized renal allograft recipients[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2009-18
Chinese Journal Full-text Database 10 Hits
1 XIAO Li,SHI Bingyi,WANG Zhen,QIAN Yeyong,CHANG Jingyuan,BAI Hongwei,HAN Mengxia The organ transplant center of P.L.A.,Second Affiliated Hospital of PLA General Hospital,Beijing 100091;Short-term anti-CD25 monoclonal antibody treatment and neogenetic CD4~+CD25~(high) regulatory T cells in kidney transplant[J];Beijing Biomedical Engineering;2008-02
2 CHEN Hao,NIE Hai-bo,HU Wei-lie,ZHU Yun-song,ZHAO Yong-bin,ZHANG Xiao-ming,XIAO Yuan-song(Department of Urology,Guangzhou General Hospital,Guangzhou Military Command Area,Guangzhou 510010,China);Peri-operative protein A immunoadsorption in sensitized renal transplant recipients:a case report and literature review[J];Acta Academiae Medicinae Militaris Tertiae;2006-13
3 SHA Guo-zhu,YIN Guang, JI Da-xi,CHEN Hui-ping, JI Shu-ming, CHEN Jin-song, YIN Li-ping, TANG Zheng,LIU Zhi-hong,LI Lei-shi (Research Institute of Nephrology of PLA, Nanjing General Hospital of Nanjing Command,Nanjing 210002,Jiangsu,China);Immunoadsorption and tacrolimus-mycophenolate-methylprednisolone rescue for accelerated acute rejection in kindeny transplantation[J];Journal of Medical Postgraduates;2004-03
4 SUN Linlin,YE Chaoyang,RONG Shu,et al Nephrology Department of Changzheng Hospital,NephrologyInstitute of PLA,Shanghai(200003);Immunoadsorption in the Treatment of Highly Sensitized Recipents of Renal Allografts[J];Chinese Journal of Integrated Traditional and Western Nephrology;2007-10
5 ZHU Dong-feng,WANG Yue,ZHEN Shou-hua,The First Attatched Hospital to Zhenzhou University,Zhenzhou,Henan Province,476400;Effects of Basiliximab on the Serum IL-2 and Serum Scr of Kindney Transplantation Recipients[J];Journal of Military Surgeon in Southwest China;2006-01
6 HAN Zhiwu,YAO Guoqian, XU Youping, et al. The PLA 161 Hospital, Wuhan 430010, China;Observation on Long-term Effect of Immunoadsorption Therapy on Lupus Nephritis[J];Journal of Internal Intensive Medicine;2008-02
7 JI Daxi, GONG Dehua, REN Bing, XU Bing, LIU Yun, ZHANG Yidan, XI E Honglang, TAO Jing, HU Weixing, LIU Zhihong, LI Leishi Reseach Institute of Nephrology, Jinling Hospital, Nanjing University, School of Medicine, Nanjing 210002;Clinical application and effects of the protein A-b ased immunoadsorption[J];Chinese Journal of Nephrology Dialysis & Transplantion;2004-05
8 Xiong ZH,Lin Z,Chen J,Zhang YB,Hu ZX,Zhang Y.Department of Urinary Surgery,Anhui General Forces Hospital,Chinese People's Armed Police Forces,Hefei 230041,Anhui Province,China;Interleukin-2-receptor monoclonal antibody for prevention of acute rejection after renal transplantation[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2007-16
9 HUANG Jian-hong,ZHANG Chun-yang.(Department of Urology,Liaoning Medical University Affiliated NO.1 Hospital,Jinzhou 121001,China);The Application of Monoclonal Antibodies in Immunosuppressive Strategies of Renal Transplantation[J];Medical Recapitulate;2008-05
10 XIAO Qiong and JIANG Nan;Nursing of patient for immunoabsorption therapy[J];Chinese Journal of Nursing;2001-11
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