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《Shandong Medical Journal》 2007-11
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S100 protein and NSE changes during cardiopulmonary bypass in infants and intervention effects of shenfu injection on them

LI Da-zhen,YE Mao,XU Ying,SHI Yuan (Children Hospital Affiliated to Chongqing Medical University,Chongqing,P.R.China)  
[Objective] To evaluate the effects of shenfu injection on the S100 protein and NSE during infants cardiopulmonary bypass(CPB),and approach its mechanism for brain protection.[Methods] Thirty-six patients with congenital heart disease within three years old were randomly divided into control group and Shenfu group,18cases in each group.Before CPB,1 ml/kg of shenfu injection and saline solution were given in Shenfu group and control group respectively.Sample were obtained at the point of induction of anesthesia(T1),CPB began(T2),aortic off-clamping(T3),CPB 20 min(T4),the end of CPB(T5),6 h and 24 h after operation for measuring S100 protein and NSE concentrations by ELISA in two groups.[Results] S100 protein and NSE were significantly higher at the point of T4 T5 and T6 than those at the point of T1(P0.05).S100 and NSE of shenfu group were significantly lower than those of control group(P0.05) at the point of T4.[Conclusion] Shenfu injection can decrease the level of S100 protein and has a brain protecting effect.
【Fund】: 重庆市卫生局中医药资助项目(2004-B-68)
【CateGory Index】: R726.5
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【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 CHENG Fa-feng,GUO Shao-ying,ZHONG Xiang-gen,LU Yi,WANG Qing-guo (School of Preclinical Medicine,Beijing University of TCM,Beijing,100029,China);Study on the Therapeutic time window of Qingkailing’s neuroprotective effect in a mouse model of FCIR[J];China Journal of Traditional Chinese Medicine and Pharmacy;2010-12
2 LI Yang,YANG Bo,CHEN Shao-Yang,et al.Department of Anesthesiology,Xijing Hospital,The Fourth Military Medical University,Xi'an 710032, China;Effects of shenfu injection pretreatment on the expression of HSP70 and HSP90 after cerebral ischemia-reperfusion injury in rats[J];The Journal of Clinical Anesthesiology;2010-01
3 GUO Hong-mei,GUO Bing,HU Dian-lei,et al (Department of Clinical Laboratory Medieine,No.3 Hospital of Xuzhou,Jiangsu Province, 221005, China);The clinical significance of serum S-100B protein in the levels of head injury[J];Zhejiang Journal of Laboratory Medicine;2005-01
4 JIANG Cui-lan1,CHEN Hong-yan2,HAN Ji-hong1,ZHANG Zhi-dong1,DU Hui-ru1(1.Department of Pharmaceutical Engineering,Hebei Chemical&Pharmaceutical Vocational Technology College,Shijiazhuang,Hebei,050026 P.R.China;2.Shjjiazhuang Yiling Pharmaceutical Inc.Shijiazhuang,Hebei,050035 P.R.China);Study on fingerprint of ginsenosides in Shenfu injection by HPLC[J];West China Journal of Pharmaceutical Sciences;2010-04
5 QIN Jing1,3,HU Hai-yang2,KANG Shuang-ming2,ZHOU Peng-cheng2,CHEN Da-wei2(1 Department of Pharmacy,Fudan University,Shanghai 201203,China; 2 School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China; 3 National Pharmaceutical Engineering Research Center of Shanghai Institute of Pharmaceutical Industry,Shanghai 200437,China);Antioxidative activity of RGD-mediated ferulic acid liposome in rats[J];Chinese Journal of New Drugs;2010-12
6 WU Chun,et al (Department of Pediatric Heart-thoracic Surgery,the Children's Hospital,Chongqing Medical University);Study of brain damage by cardiopulmonary bypass in infants[J];Journal of Chongqing Medical University;2010-07
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