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《Shandong Medical Journal》 2007-11
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S100 protein and NSE changes during cardiopulmonary bypass in infants and intervention effects of shenfu injection on them

LI Da-zhen,YE Mao,XU Ying,SHI Yuan (Children Hospital Affiliated to Chongqing Medical University,Chongqing,P.R.China)  
[Objective] To evaluate the effects of shenfu injection on the S100 protein and NSE during infants cardiopulmonary bypass(CPB),and approach its mechanism for brain protection.[Methods] Thirty-six patients with congenital heart disease within three years old were randomly divided into control group and Shenfu group,18cases in each group.Before CPB,1 ml/kg of shenfu injection and saline solution were given in Shenfu group and control group respectively.Sample were obtained at the point of induction of anesthesia(T1),CPB began(T2),aortic off-clamping(T3),CPB 20 min(T4),the end of CPB(T5),6 h and 24 h after operation for measuring S100 protein and NSE concentrations by ELISA in two groups.[Results] S100 protein and NSE were significantly higher at the point of T4 T5 and T6 than those at the point of T1(P0.05).S100 and NSE of shenfu group were significantly lower than those of control group(P0.05) at the point of T4.[Conclusion] Shenfu injection can decrease the level of S100 protein and has a brain protecting effect.
【Fund】: 重庆市卫生局中医药资助项目(2004-B-68)
【CateGory Index】: R726.5
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Chinese Journal Full-text Database 6 Hits
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