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《Shandong Medical Journal》 2007-25
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Study of T subsets and haematogenesis negative regulatory factors during non-myeloablativehematopoietic stem cell transplantation in patients with severe aplastic anemia

GE Lin-fu,YU Zhe,LIU Xi-min,HUANG Ning,ZHOU Fang,KONG Fan-sheng(General Hospital of Jinan Military PLA,Jinan 250031,P.R.China)  
[Objective] To detect the level of T cell subsets and haematogenesis negative regulatory factor,and analyze the correlateion between their abnormality and curative effect,and evaluate the role and significance of NSCT in SAA pathogenesis.[Methods] T cell subsets,IFN-γ and IL-2 of peripheral blood in 30 grave SAA patients(SAA group) and 16 healthy volunteers(control group)were detected by flow cytometry(FACS).[Results] In SAA group,76.6% T cell subsets were anomal,the levels of IFN-γ and IL-2 were higher than that of control group(P0.01);Patients with T cell subsets abnormality and higher level of IL-2,IFN-γ had high clinical effective rate than those with normal T cell subsets and normal/lower IL-2 and IFN-γ;T cell subsets and plasma cytokines in part patients revived after one year.[Conclusion] Abnormally high and activated immune effector cells can damage myeloid directly or indirectly.That may be a important mechanism of SAA;NSCT may influence the level of T cell subsets and plasma cytokines in SAA patients.
【CateGory Index】: R556
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