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《Shandong Medical Journal》 2007-32
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Effect of edaravone on plasma ET,CGRP and serum SOD in the patients with acute cerebral injury

ZHU Jian-cheng,ZHOU Zhang-ming,LI Jiong,HUANG Kai-he,WANG Dan,SONG Deng-peng(Taihe Affiliated Hospital of Yunyang Medical College,Shiyan 442000,P.R.China)  
[Objective] To study the effect of edaravone on the plasma endothelin(ET),calcitonin gene-related peptide(CGRP) and serum superoxide dismutase(SOD) in patients with acute cerebral injury(ACI) who were underwent craniotomy.[Methods] 40 patients were divided into the edaravone group and the contral group randomly.Plasma ET,CGRP were determined by radioimmunoassay method and serum SOD were determined by xanthine oxidase method.And another 40 healthy blood donors were normal group.[Results] ET was significantly increased before neurosurgery in patients with ACI compared to normal group(P0.01).SOD was significantly decreased(P0.01).120 minutes after craniotomy,ET was significantly increased(P0.01),CGRP and SOD was significantly decreased in patients with ACI(P0.05).30 minutes after treatment with edaravone,SOD and CGRP were significantly increased(P0.01) and the ET was significantly decreased(P0.01).[Conclusion] Therapeutic dose of edaravone may markedly increase SOD and CGRP in vivo, and also antagonistic effect on the content of ET,and it may be effective for treatment in acute cerebral injury.
【CateGory Index】: R651.15
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