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《Shandong Medical Journal》 2007-32
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Effect of edaravone on plasma ET,CGRP and serum SOD in the patients with acute cerebral injury

ZHU Jian-cheng,ZHOU Zhang-ming,LI Jiong,HUANG Kai-he,WANG Dan,SONG Deng-peng(Taihe Affiliated Hospital of Yunyang Medical College,Shiyan 442000,P.R.China)  
[Objective] To study the effect of edaravone on the plasma endothelin(ET),calcitonin gene-related peptide(CGRP) and serum superoxide dismutase(SOD) in patients with acute cerebral injury(ACI) who were underwent craniotomy.[Methods] 40 patients were divided into the edaravone group and the contral group randomly.Plasma ET,CGRP were determined by radioimmunoassay method and serum SOD were determined by xanthine oxidase method.And another 40 healthy blood donors were normal group.[Results] ET was significantly increased before neurosurgery in patients with ACI compared to normal group(P0.01).SOD was significantly decreased(P0.01).120 minutes after craniotomy,ET was significantly increased(P0.01),CGRP and SOD was significantly decreased in patients with ACI(P0.05).30 minutes after treatment with edaravone,SOD and CGRP were significantly increased(P0.01) and the ET was significantly decreased(P0.01).[Conclusion] Therapeutic dose of edaravone may markedly increase SOD and CGRP in vivo, and also antagonistic effect on the content of ET,and it may be effective for treatment in acute cerebral injury.
【CateGory Index】: R651.15
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【References】
Chinese Journal Full-text Database 1 Hits
1 CHENG Fa-feng1,SONG Wen-ting2,GUO Shao-ying1,ZHONG Xiang-gen1,LU Yi1,WANG Qing-guo1(1School of Preclinical Medicine,Beijing University of Chinese Medicine,Beijing 100029,China;2Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China);Protective effect of baicalin on H_2O_2 injured rats' primary cortical neurons[J];China Journal of Traditional Chinese Medicine and Pharmacy;2011-05
【Co-references】
Chinese Journal Full-text Database 8 Hits
1 Xu Ya1 Li Pengtao1 Xie Lijun2 Jia Xu1 Zhu Xiaolei3(1Beijing University of Traditional Chinese Medicine,Beijing 100029;2 The Third hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100029;3The World Federation of TCM Societies,Beijing 100101);Effects of Different Compositions of Qing Kai Ling Injection on Tumor Necrosis Factor in Brain of Rats with MCAO[J];China Journal of Traditional Chinese Medicine and Pharmacy;2007-07
2 WANG Ning, XUE Yuan, SUN Ti-jian (Dept of Chemistry,Shanxi Medical University, Taiyuan 030001,China);Scavenging effects of red pigment extracted from edible amaranth on hydroxyl radicals and superoxide anion radicals[J];Journal of Shanxi Medical University;2009-05
3 ZHANG Jian-ping1,2,YI Xing1,2*,XIAO Xiao-nian1(1.Key Laboratory of Food Science of Ministry of Education,Nanchang University,Nanchang,330047,China;2.Sino-German Food Engineering Center,Nanchang University,Nanchang,330047,China);Free Radical Scavenging Activity of the Extracts from Alisma orientalis[J];Lishizhen Medicine and Materia Medica Research;2009-05
4 Fu Xiaochun,Xu Zhe,He Ying,Chi Haiyang(Guangdong Food and Drug Vocational and Educational College,Guangzhou 510600, Guangdong,China);Protective function of Huanglian Jiedu Tang on Rats after focal cerebral ischemic reperfusion and its influence on caspase-3 expression[J];Modern Journal of Integrated Traditional Chinese and Western Medicine;2009-14
5 Yang Xian Yang1,Wei Dong Yan1,Jin Qiao2,Yun Cai1,1Department of Traditional Chinese Medicine,2Department of Neurology,First Hospital of Xi'an Jiaotong University,Xi'an 710061,Shaanxi Province,China Xin Min Li,Department of Biochemistry,Medical College of Xi'an Jiaotong University,Xi'an 710061,Shaanxi Province,China;Effect of baicalin on the levels of superoxide dismutase and malondialdehyde in the brain tissue of rats after cerebral ischemia reperfusion[J];Chinese Journal of Clinical Rehabilitation;2004-28
6 ZHOU Ling,ZHOU Bi-ying.Department of Traditional Chinese Medicine,the Affiliated Hospital of Zunyi Medical College(Zunyi 563003,China);Influence of baicalin on superoxide dismutase and malondialdehyde in rats with Pneumocystis carinii pneumonia[J];Chinese Journal of Public Health;2009-06
7 WANG Wen,SUN Fang-ling,AN Yi,et al.Department of Pharmacology,Xuanwu Hospital of Capital Medical University,Key Laboratory for Neurodegenerative Disease Ministry of Education,Beijing 100053,China;Morroniside Inhibits Hydrogen Peroxide-induced Calcium Overload and Cytotoxicity in SH-SY5Y Neuroblastoma Cells[J];Chinese Journal of Rehabilitation Theory and Practice;2009-03
8 SU Ning1,LUO Rongjing1,SU Hang2,LUO Hui1,LANG Jianying1,NONG Hui1,LI Li1 (1.Basic Medical College,Guangzhou University of TCM,Guangzhou 510006;2. Dept. of Clinical Molecular Medicine,the Second Affiliated Hospital of Guangzhou Medical College,Guangzhou 510260);Effect of Baicalin on Renal Function in Diabetic Nephropathy Rats and Its Anti-oxidative Action[J];Traditional Chinese Drug Research & Clinical Pharmacology;2007-05
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