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《Shandong Medical Journal》 2012-09
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Effect of taurine on cerebral blood flow of rats with acute severe traumatic brain injury

MO Li-dong1,HUANG Hui-ling,ZHANG Xue-bin,CHANG Xiao-li,WANG Chen,FAN Wei-jia(1 Institute of Neurosurgical Research,Tianjin Huanhu Hospital,Tianjin 300060,P.R.China)  
Objective To investigate the changes of rat cerebral cortex blood flow(CBF)after acute severe traumatic brain injury(TBI) and the effects treated by taurine(Tau).Methods Forty SD rats were randomly divided into sham operation group(group sham),brain trauma group(group TBI),Tau low dose group(100 mg/ kg),high dose of Tau group(200 mg/kg) equally.TBI models were made in left brain of rats by hydraulic shock,while sham group only opened bone window.Rats in group Tau were given Tau immediately after injury injected via tail vein;And group sham,group TBI was given the same amount of physiological saline.Laser doppler flowmetry was used to monitor the cerebral cortex CBF of each group in the time before trauma,30 min after injury and 24 h before puting to death.Results There was no statistical significance of CBF in each group before injury;CBF in group TBI was significantly lower than that in group sham on points 30 min or 24 h after injury(P0.05).The left brain: compared with TBI group,CBF in group Tau low dose showed no significant difference,whereas high dose of Tau group CBF significantly increased(P0.01);CBF on 24 h after injury was significantly higher than that on 30 min after injury in group Tau high or low dose(P0.05).The right brain: compared with group TBI,CBF in Tau low dose group was no significant difference on 30 min after injury,but increased obviously after 24 h(P0.05);CBF in Tau high dose group increased significantly on 30 min and 24 h after injury(P0.05);there was no statistical significance overall between group Tau high and low dose.Left and right brain: CBF TBI of left brain was significantly lower than that of right brain on 30 min after injury in all three groups,and there was no statistical significance between each group on 24 h after injury.Conclusions Tau treatment helps improve CBF after TBI,and its improvement is positively related to administration time,dosage.
【Fund】: 国家自然科学基金资助项目(30973089);; 天津市应用基础及前沿技术研究计划(10JCYBJC12200)
【CateGory Index】: R651.1
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