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《Shandong Medical Journal》 2012-38
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Effection of acute regional contusion and laceration to the rat brain local cerebral blood flow

YANG Xiao-hong1,WANG Chun-li(1 First Affiliated Hospital of Hebei North University,Zhangjiakou075000,P.R.China)  
Objective To explore the the changement law of local cerebral blood flow after contusion and laceration of brain injury.Methods A total of 81 adult Wister rats were injured to establish rat focal brain contusion and laceration model according to Feeney ' s free-falling impact method.The rats were randomly divided into 9 groups according to the observing time point(30 minutes,2 hours,6 hours,12 hours,1 days,2 days,3 days,7 days and the control group).Laser Doppler flowmetry was used to detect rat local cerebral blood flow before and after injury.The animal brain tissue were fixed in glutaraldehyde to observe microvascular endothelial structure ultrastructure with electron microscope.Results The level of rCBF in each group before injury have no statistical significance.The rCBF level of rats in 30 minutes group was significantly decreased after injury and getting the lowest level until 6 hours after the injury(P0.01).The level of rats in 7 days group remain significantly lower than that of control group.The vascular endothelial cells impaired mildly after injury 30 minutes,endovascular microvillus formed after 2 hours,villus increased after 6 hours,capillary stenosis was noticed in 12 to 72 hours.Conclusions There are hypoperfusion of brain regional tissue after cerebral contusion and laceration at early phase,which is considered to be the main reason cerebral edema and ischemic damage of nervous system.Microvascular endothelial cell damage and secondary thrombosis is the fundamental pathological change.
【Fund】: 河北省卫生厅医学科学研究重点课题计划项目(06241)
【CateGory Index】: R651.15
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