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《Shandong Medical Journal》 2014-08
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Analysis of plasma angiopoietin-2,(1,3)-β-D glucan levels and their correlation in septic patients

CHEN Qiu-ping;FENG Yong-min;ZHANG Yuan-li;YAO Hua-guo;DENG Lie-hua;HE Hui-juan;Affiliated Hospital of Guangdong Medical College;  
Objective To investigate the plasma levels of angiopoietin-2( Ang-2),( 1,3)-β-D-glucan( BG) and their correlation in septic patients. Methods Sixty-six septic patients were divided into three groups: the deep fungal infection group( n = 11,group A),the double infection group caused by fungi and gram-negative bacteria( n = 36,group B) and the gram-negative bacteria infection group( n = 20,group C). The healthy volunteers were selected as the control group( n = 20,group D). The acute physiology and chronic health conditions( APACHE) Ⅱ score and sequential organ failure assessment( SOFA) score were recorded within 24 hours. Plasma Ang-2 and BG levels were detected. Results Plasma Ang-2 levels were significantly higher in the three septic groups than that in the group D( all P 0. 05). There were no significant differences in the plasma levels of Ang-2 among these three septic groups( P 0. 05). Plasma BG levels were all significantly higher in the three septic groups than that of group D( all P 0. 05). The plasma BG levels in group A and group B were significantly higher than that of group C( P 0. 05). There was no significant difference in plasma( 1,3)-β-D BG levels between group A and group B( P 0. 05). The plasma Ang-2 level in septic patients was positively correlated with scores of APACHE Ⅱ and SOFA( r = 0. 599,P 0. 05; r = 0. 723,P 0. 05,respectively). The plasma Ang-2 level was independently correlated with the score of APACHE Ⅱ and SOFA in septic patients( β = 0. 468,P 0. 05; β = 0. 626, P 0. 001,respectively). The plasma Ang-2 level was positively correlated with plasma BG level in septic patients except group C( r = 0. 371,P 0. 05). BG level was independently associated with Ang-2 level in septic patients( β = 0. 393,P 0. 05). Conclusions Plasma Ang-2 and BG levels increase in septic patients. Ang-2 level is an independent risk factor which is associated with the severity of septic patients. BG is an independent risk factor which is associated with plasma Ang-2 level in septic patients with fungal infection.
【Fund】: 广东省医学科研基金项目(A2009484);; 广东省湛江市科技攻关计划项目(2013B01042)
【CateGory Index】: R459.7
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