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《Shandong Journal of Traditional Chinese Medcine》 2002-08
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Protective effect and mechanism of tetramethylpyrazine on small intestinal ischemia reperfusion injury in rats

ZHU Xiao qing 1,LEI Shui sheng 1,HU Qi sheng 2 (1 Xianning Medical College,Xianning 437100,China; 2 Medical College of Wuhan University,Wuhan 430071,China)  
Objective:To study the effective prevention and therapy method for small intestinal ischemia/reperfusion(I/R)injury in rats Methods:Thirty SD rats were divided into three groups randomly Anesthetized SD rats underwent superior mesenteric artery occlusion for 60 min(n=10)or sham operation(n=10)and were observed for 100 min of reperfusion The rats in the other group(n=10) underwent I/R in the same way,but 20 min before reperfusion,were injected with tetramethylpyrazine(TMP)(8 mg/kg)iv TMP were given the second time following reperfusion with the same does All the rats were injected with Evans Blue(EB,15 mg/kg)50 min before sacrifice Blood pressure,water content and lung were observed to evaluate the effect of drugs and EB content of intestine Results:TMP was improved sharply(P0 01) The tissue contained less water(P0 01)and EB (P0 05) The accumulating survial rate within 100 min was improved obviously(100% vs 0,P0 05) Conclusion:TMP can attenuate small intestinal I/R injury apparently
【Fund】: 湖北省自然科学基金资助项目 ( 2 0 0 0 J0 78)
【CateGory Index】: R285.5
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