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《Journal of Practical Obstetrics and Gynecology》 2002-04
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Comparative Study on three Chemotherapeutic Regimens for the Treatment of Advanced Epithelial Ovarian Cancer

WANG Chang-yu,GU Mei-jiao,WANG Shi-xuan,et al (Tongji Hospital,Tongji Medical University,Wuhan 430030)  
Objective:To investigate the best first-line chemotherapy regimen for the treatment of advanced epithelial ovarian cancer.Methods: The efficacy of three chemotherapy regimens for treatment of the patients with advanced epithelial ovarian cancer in our hospital during 1992~1999 was retrospectively analyzed.The results were compared with the supplement of PAM+HMM(Melphalan+Hexamethylme),PAC or PC,TP combined chemotherapy after cytoreductive surgery.Results: ①The overall response rate of TP is significantly higher than that of PAM+HMM(P0.05);②The complete response rate of TP is significantly higher than those of PAM+HMM and PAC or PC(P0.05,respectively);③The 2-year survival rate free of tumor of TP is obviously higher than those of PAM+HMM and PAC or PC(P0.05,respectively).Conclusion: We conclude that the TP regimen is better than PAM+HMM and PAC or PC,it is currently the preferred first-line regimen for treatment of advanced epithelial ovarian cancer.
【CateGory Index】: R737.31
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