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《上海第二医科大学学报(英文版)》 2004-01
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MECHANISM OF PATHOLOGICAL CHANGES OF INTRAVENTRICULAR HEMORRHAGE IN DOGS

DAI Jiong LI Shan-quan, LI Xiao-xiong XU Bin-bin XIONG Wen-hao,WANG Yong,ZhANG Xiao-hua Department of Neurosurgery, Renji Hospital, SSMU, Shanghai 200001, China SHEN Jia-lin Department of Radiology, Renji Hospital, SSMU, Shanghai 200001, China  
Objective To probe the mechanism of pathological changes of intraventricular hemorrhage (IVH). Methods The evaluation of neurological status,serial CT scans and pathological examination were applied on the canine model of IVH. The ventricular volume and blood clot volume were measured based on the CT images. Results The normal adult canine ventricle tend to be slitlike. After injection, the ventricle was obviously dilated by the blood clot. The linear regression of ventricular volume against blood clot volume was significant in the first week. From then on, however, while the clots continued to shrink, the ventricular volume showed progressive enlargement. The clots were lysed completely within 3 to 4 weeks. The linear regression of the degree of ventricular dilatation against the first clot volume was also significant. In the pathological examination, we found the ependymal lining of ventricular system was destroyed and neurons in the subependymal areas developed acidophil necrosis, which was prominent around Sylvian aqueduct. Conclusion Hemorrhagic ventricular dilatation(HVD) is a prominent feature of IVH and also is a strong indicator for poor prognosis. Ischemic changes of periventricular neurons in some important structures may be the most direct cause for poor outcome of IVH. It may be induced by periventricular vascular structures compressed by HVD, increased intracranial pressure, cerebral vasospasm and others.
【CateGory Index】: R651.1
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【References】
Chinese Journal Full-text Database 1 Hits
1 GONG Guo-qi,MENG Hui,XIA Yong-zhi,FENG Hua(Department of Neurosurgery,Southwest Hospital,Third Military Medicine University,Chongqing 400038,China);Experimental chronic hydrocephalus after intraventricular hemorrhage in rats:establishment of animal model and pathological observation[J];Acta Academiae Medicinae Militaris Tertiae;2008-10
【Co-references】
Chinese Journal Full-text Database 1 Hits
1 MENG Hui,ZHANG Lijun,LU Jiayou,et al Department of Neurosurgery,the PLA Army Minimally Invasive Treatment of Nervous System Diseases Specialist Centers,Southwest Hospital,Third Military Medicine University,Chongqing 400038,China;Levels and their significance of PⅠCP,PⅢNP,HA and laminin in cerebrospinal fluid in posthaemorrhagic chronic hydrocephalus[J];Chinese Journal of Minimally Invasive Neurosurgery;2007-02
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 GONG Guo-qi,MENG Hui,FENG Hua (Department of Neurosurgery,Southwest Hospital,Third Military Medicine University,Chongqing 400038,China);Role of iron ion in development of hydrocephalus in rats[J];Acta Academiae Medicinae Militaris Tertiae;2008-23
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