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《Acta Universitatis Medicinalis Secondae Shanghai》 1990-03
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Effects of Radix Salviae Miltiorrhizae and Its Component "Danshensu" on the Anticoagulant and Fibrinolytic Functions of Cultured Bovine Endothetial Cells

Gu Yanghong, et al Department of Pathophysiology, Shanghai Institute of Hematology, Shanghai Second Medical University, Shanghai  
The effects of injectio Salviae Miltiorrhizae and its component "Danshensu" on the production of PA, PAI which are related with fibrinolytic system, on PGI_2 related with anticoagulant system and on the expression of throm-bomodulin in Cultured bovine endothetial cells were studied. 6-keto-PGF1_a was measured with RIA, PA, PAI and thrombomodulin activities were measured with chromogenic substrates S_(2390) and S_(2238) respectively. The results showed that injectio Radix Salviae Miltiorrhizae could promote PA activity aud PGI_2 produced by bovine endothelial cells (BEC). It could inhibit PAI activity produced by BEC. Its component "Danshensu" had the same effects. Beside, injectio Salviae Miltiorrhizae could increase thrombomodulin activity on the surface of BEC, whereas "Danshensu" could not.
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