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The Inhibitory Effects of Salvia Miltiorrhiza and Aristolochia on Matrix Production in Fibroblasts

Zeng Minde, et al Shanghai Instite of Digestive Disease, Shanghai Second Medical University, Shanghai  
The ~3H-hydroxyproline, P-Ⅲ-P and fibronectins produced by fibroblasts in 10% FCS BME with Salvia miltiorrhiza, Aristolochia, colchicine or dexamethasone were determined. The contents of ~3H-hydroxyproline incorporating into the fibroblasts cultured with different drug were 1/3-1/2 of that in the culture without drug(P0.05). The collagen synthesis rates of cultures with drugs were 3.6-9.5%, while that of the control culture was 13.7%. The fibronectines produced by fibrobiasts cultured with Salvia miltiorrhiza, Aristolochia or colchicine were half in amount as that produced by the control (P0.005). The amounts of P-Ⅲ-P in the cultures with Salvia miltiorrhiza or colchicine were decreased to one third of the control (P0.01). This study indicates that Salvia miltiorrhiza and Aristolochia can considerably inhibit both fibroblasts and their synthesizing activity of matrix.
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