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《Acta Universitatis Medicinalis Secondae Shanghai》 2002-03
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Therapeutic Efficacy of Astragalus in Patients with Chronic Glomerulonephritis

SHI Jun-feng, ZHU Han-wei, Zhang Chong, et al(Department of Nephrology, Xinhua Hospital, SSMU, Shanghai 200092, China)  
To investigate the therapeutic efficacy of astragalus injection on proteinuria as well as to observe the relationship between the efficacy of T - lymphocyte subsets and cytokine receptors in patients with chronic glomerulonephritis. Methods Changes in proteinuria, serum CD3, CD4 and CD8 levels, of CD4/CD8 ratio and serum SIL- 2R, SIL- 6R were determined in 30 patients with chronic glomerulonephritis, before and after treatment with astragalus injection (40ml/d) for 3 weeks. Results Proteinuria dropped from (2328.10 ± 3 157.18)mg/24h to (1 017. 21 ± 765. 39)mg/24h (P 0.01) , CD4 le-vels were lowered from 45.54% ± 8.99% to 40.77% ± 8.30% (P 0.05) , CD8 levels were increased from 25.33% ± 9. 53% to 27. 74% ± 8. 24% (P 0.01) , and the ratio of CD4/CD8 fell from 2. 56 ± 2. 36 to 1. 70 ± 0. 92 (P 0. 05) . There were also significant decreases in serum SIL - 2R from (673.08 ± 451.87)ng/L to (548.95 ± 342.86)ng/L (P 0.05) and SIL - 6R from (43.22 ± 14.39)ng/ L to (36.18± 9.51)ng/L (P 0.05) . Conclusion Astragalus injection can be used safely to alleviate proteinuria and adjust cellular immunological functions in certain patients with chronic glomerulonephritis.
【CateGory Index】: R692.31
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