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《Acta Universitatis Medicinalis Secondae Shanghai》 2005-07
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Current Research Progresses of FOXC2

LIU Min reviewer, LIU Wei reviser (Department of Endocrinology and Metabolism, Renji Hospital, Shanghai Second Medical University, Shanghai200127, China)  
Obesity, hyperlipidemia, and insulin resistance are common forerunners of type 2 diabetes mellitus. People have identified forkhead box C2(FOXC2),a transcriptional factor of forkhead family, as the key regulator of adipocyte metabolism. Increased adipocyte FOXC2 expression had a pleiotropic effect on the expression of genes influencing cellular differentiation and metabolism, insulin action, β-adrenergic sensitivity, and intracellular signaling. FOXC2 affects adipocyte metabolism by increasing the sensitivity of the β-adrenergic-cAMP-protein kinase A (PKA) signaling pathway through alteration of adipocyte PKA holoenzyme composition. Increased FOXC2 levels seem to counteract most of the symptoms associated with obesity, including hypertriglyceridemia and diet-induced insulin resistance. Therefore, FOXC2 is likely to play the role as a metabolic regulator which can counteract not only obesity,and insulin resistance, but also type 2 diabetes mellitus.
【Fund】: 上海第二医科大学自然科学基金(02XJ21016)资助项目.
【CateGory Index】: R58
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